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Completed

NCT Number: NCT06730698

Thumb Muscle Thickness and Strength in CMC Osteoarthritis

A total of 34 patients aged between 50-80 years, diagnosed with first carpometacarpal joint osteoarthritis based on hand radiographs taken within the last 3 months, will be included in the study from the Physical Therapy and Rehabilitation outpatient clinic. Sociodemographic data such as age, gender, height, weight, and BMI will be recorded. Based on their current radiographs, patients will be classified into two groups according to the Eaton-Littler classification: Stage 1-2 (early stage) and Stage 3-4 (advanced stage). Pain levels will be assessed using the Visual Analog Scale (VAS). Hand grip strength will be evaluated with a Jamar hand dynamometer, and pinch grip strength will be assessed with a Jamar pinch meter. The thicknesses of the abductor pollicis brevis, first dorsal interosseous, and opponens pollicis muscles will be measured using ultrasound. All assessments will be performed separately for the dominant and non-dominant hands.

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Key information

Conditions

Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Rheumatic Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Beylikdüzü State Hospital

Istanbul, Beylikdüzü, 34147, Turkey (Türkiye)

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 50-80 years.
  • Diagnosed with first carpometacarpal joint osteoarthritis.
  • Presence of a hand radiograph taken within the last 3 months.
  • Volunteered to participate in the study.

Exclusion criteria

  • Refusal to participate in the study.
  • Use of medications that may suppress osteoarthritis flares.
  • Presence of rheumatologic diseases causing peripheral joint involvement.
  • History of fractures or surgeries involving the first carpometacarpal joint.
  • Presence of psychiatric disorders.
  • Presence of cognitive impairments that could hinder understanding or performance of study-related tasks.

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

  1. Thumb Muscle Thickness (Ultrasound)

    Time frame: 0 day

    Measurement of the thickness of three thumb muscles-abductor pollicis brevis, first dorsal interosseous, and opponens pollicis-using ultrasonography. These measurements will help determine muscle atrophy or hypertrophy related to disease severity and stage

Secondary outcomes

  1. Grip Strength

    Time frame: 0 day

    Assessed using a Jamar hand dynamometer. This measure evaluates overall hand strength, which is often impaired in advanced stages of carpometacarpal joint osteoarthritis.

  2. Pinch Strength

    Time frame: 0 day

    Assessed using a Jamar pinch meter. This measure evaluates the strength of the thumb-index finger pinch, a critical function for fine motor activities. It is particularly relevant to functional limitations seen in osteoarthritis.

  3. Pain Level (VAS)

    Time frame: 0 day

    Pain intensity will be measured using the Visual Analog Scale (VAS). Patients will mark their perceived pain level on a 10 cm scale, providing a quantitative measure of pain severity in both early and advanced stages.

Sponsors and collaborators

Lead sponsor

Beylikduzu State Hospital

Other

Registry information

Official study title

Ultrasonographic Measurement of Thumb Muscle Thickness and Evaluation of Pinch and Grip Strength in First Carpometacarpal Joint Osteoarthritis: A Comparison of Early and Advanced Stages

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Dec 12, 2024
Registry last updated
Mar 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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