Thermal Spa Treatment and Improvement of Primary Ciliary Dyskinesia

Inclusion criteria

• Confirmed diagnosis of Primary Ciliary Dyskinesia (PCD) based on electron microscopy analysis of ciliary ultrastructure and/or genetic testing (i.e., two unambiguous mutations in genes known to be involved in PCD, particularly in cases with normal ciliary ultrastructure [~20% of patients], atypical ultrastructural findings, or suggestive symptoms in a family with a known causal gene).
• Age over 18 years.
• Stable maintenance treatment for at least 1 month prior to inclusion.
• Performance Status (PS) ≤ 1.
• Patient has received the study information sheet and signed the informed consent form.
• Patient has valid health insurance coverage.

Exclusion criteria

• Participation in a thermal spa treatment within the past year.
• Severe general health deterioration or debilitating conditions.
• Severe or recent heart failure.
• Labile hypertension.
• Venous insufficiency or deep vein thrombosis within the past 3 months.
• Recent unhealed fracture.
• Unhealed skin lesions (wounds, pressure sores, eczema).
• Contagious or progressive diseases.
• Recent cancer (less than 5 years).
• Ongoing or recent (within the past month) pulmonary or ENT exacerbation at inclusion.
• Ongoing treatment with immunomodulatory or immunosuppressive drugs (due to the risk of potentially severe opportunistic infections).
• Ongoing or recent (within the past month) extra-respiratory or ENT infectious flare-up.
• Positive pre-cure bacteriological testing for multidrug-resistant Pseudomonas aeruginosa, MRSA, Mycobacterium abscessus, or other multidrug-resistant pathogenic bacteria.
• Fever > 38.5°C.
• Recently worsened dyspnea (< 1 month).
• History of serious adverse effects or intolerance during a previous thermal spa treatment.
• Participation in another clinical trial with an exclusion period.
• Considered a vulnerable person, as defined by Articles L1121-5 to L1121-8 of the French Public Health Code:

Pregnant women, women in labor, and breastfeeding mothers.

Individuals deprived of liberty by judicial or administrative decision, or those hospitalized without consent under Articles L.3212-1 and L.3213-1 (excluding Article L.1121-8), and persons admitted to a healthcare or social institution for reasons other than research.

Adults under legal protection or unable to give informed consent.