The Role of Topically Dissolved Oxygen (TDO) to Ameliorate Signs of Photodamage

Inclusion criteria

• Subjects must be female, 25-60 years old in good general health;
• Subjects must be Fitzpatrick Types I, II, III, IV, V
• Subjects must be willing to forgo the use of facial cosmetics (e.g. facial moisturizers,creams, foundations, blush, etc.) during the course of the study.
• Subjects may ONLY use facial regimen of products provided by sponsor(lipstick, lip gloss, and eye mascara permitted).

Exclusion criteria

• Known sensitivity to any of the test material ingredients.
• Routine high dosage use of anti-inflammatory medications (aspirin, ibuprofen, corticosteroids), immunosuppressive drugs or antihistamine medications (steroid nose drops and/or eye drops are permitted) (one-8lmg or 325mg aspirin okay) (birth control is okay but needs to be reported).
• Use of topical OTC/Rx drugs or other cosmetics at the test sites.
• Immunological disorders such as HIV positive and systemic lupus erythematosus (interview only)
• Participation in any clinical study within the last four weeks.
• Pregnant or lactating women (interview only).
• Damaged skin in or around test sites (including sunburn, uneven skin tones, tattoos, scars or other disfiguration of the test site).