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NCT Number: NCT07046039

The Impact of Untreated Depression and Anxiety Among Patients With Skin Diseases in Jeddah, Saudi Arabia.

The goal of this observational study is to learn about the prevalence and severity of untreated depression and anxiety among adults with skin diseases in Jeddah, Saudi Arabia. The main question it aims to answer is:

Do patients with skin diseases experience significant levels of untreated depression and anxiety?

Participants diagnosed with skin conditions such as acne, eczema, or psoriasis completed the PHQ-9 and GAD-7 questionnaires to assess their mental health symptoms. The study also explores whether factors like age or type of skin disease are associated with more severe psychological distress.

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Key information

Conditions

Alopecia Areata Acne Vulgaris Acneiform Eruptions Alopecia Atopic Dermatitis (Eczema) Bacterial Infections Bacterial Infections and Mycoses Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dermatitis Dermatitis, Atopic Eczema Genetic Diseases, Inborn Hair Diseases Hidradenitis Hidradenitis Suppurativa Hidradenitis Suppurativa (HS) Hypersensitivity Hypersensitivity, Immediate Hypopigmentation Hypotrichosis Immune System Diseases Infections Pigmentation Disorders Psoriasis Rosacea Sebaceous Gland Diseases Skin Diseases Skin Diseases, Bacterial Skin Diseases, Eczematous Skin Diseases, Genetic Skin Diseases, Infectious Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Suppuration Sweat Gland Diseases Vitiligo

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

King Abdulaziz University - Faculty of Medicine

Jeddah, Saudi Arabia

About this study

This cross-sectional observational study was conducted to assess the prevalence and severity of untreated depression and anxiety among adult patients diagnosed with common dermatological conditions in Jeddah, Saudi Arabia. The study focused on patients living with acne vulgaris, atopic dermatitis (eczema), psoriasis, vitiligo, rosacea, hidradenitis suppurativa, and alopecia. Conditions that are not only physically distressing but also associated with significant psychological impact.

Participants were recruited through dermatology clinics and online platforms. Standardized and validated screening tools, including the Patient Health Questionnaire-9 (PHQ-9) and the Generalized Anxiety Disorder-7 (GAD-7), were used to evaluate symptoms of depression and anxiety. Participants were eligible if they were between 18-65 years old, residing in Jeddah, and had not received prior psychiatric treatment for depression or anxiety.

The study also examined potential correlations between psychological distress and clinical or demographic variables such as age, sex, income level, education, and disease severity. Statistical analyses were conducted to identify significant predictors of untreated mental health symptoms in this population.

By quantifying the emotional burden associated with skin disease and identifying at-risk subgroups, the study aims to support the integration of routine mental health screening into dermatologic practice. The findings underscore the need for a more comprehensive, biopsychosocial approach to dermatology care in Saudi Arabia, where psychological symptoms are often underrecognized and undertreated.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Inclusion Criteria:
  • Adults aged 18 to 65 years
  • Residents of Jeddah, Saudi Arabia
  • Diagnosed with one or more of the following skin diseases: acne vulgaris, atopic dermatitis (eczema), psoriasis, vitiligo, rosacea, hidradenitis suppurativa, or alopecia areata
  • Able to complete the study questionnaire in Arabic or English
  • Exclusion Criteria:
  • Age below 18 or above 65 years
  • Absence of diagnosis for the specified skin diseases
  • Presence of chronic systemic illnesses such as diabetes, cardiovascular diseases, hypertension, or epilepsy
  • Inability to provide informed consent or complete the questionnaire

Treatment and study plan

Primary outcomes

  1. Prevalence of untreated anxiety

    Time frame: 1 day (Assessed at one point in time during the study.)

    The proportion of patients with dermatological conditions who score above the clinical threshold for anxiety on the Generalized Anxiety Disorder-7 (GAD-7) scale.

  2. Prevalence of untreated depression

    Time frame: 1 day (Assessed at one point in time during the study.)

    The proportion of patients with dermatological conditions who score above the clinical threshold for depression on the Patient Health Questionnaire-9 (PHQ-9).

Secondary outcomes

  1. Correlation between skin disease severity and psychological distress

    Time frame: 1 day (Assessed at one point in time during the study.)

    Statistical assessment of the relationship between the severity of skin diseases (categorized as mild, moderate, or severe) and the levels of depression and anxiety symptoms.

Sponsors and collaborators

Lead sponsor

King Abdulaziz University

Other

Registry information

Official study title

The Impact of Untreated Depression and Anxiety in Patients With Skin Diseases: A Cross-sectional Study in Jeddah

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jul 1, 2025
Registry last updated
Jul 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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