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OpenTrials
Completed

NCT Number: NCT01918566

The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Completed

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Key information

Conditions

Exploratory Behavior Behavior

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital

Basel, CH-4031, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • right-handed healthy males, no drugs, non-smoking

Exclusion criteria

  • drug abuse, smoker, left-handed, claustrophobia

Treatment and study plan

tap water

Dietary Supplement

Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

Dietary Supplement

Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole

Dietary Supplement

25g Fructose in 300ml tap water

Dietary Supplement

75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39

Dietary Supplement

300ml tap water with 450ppm lactisole

Dietary Supplement

Primary outcomes

  1. Functional magnetic resonance imaging (fMRI) in healthy volunteers while they performed a working memory task: changes in cerebral blood flow and blood hormones from baseline to treatment

    Time frame: changes from baseline to one hour after treatment

    Whole brain analysis with a cluster-level threshold was followed by an a priori defined region of interest analysis of the dorsolateral prefrontal cortex including a cluster-level threshold and family-wise error adjustment for multiple comparisons.

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

The Role of Endogenous GLP-1 in Regulating Glucose Stimulated Brain Activity

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Aug 7, 2013
Registry last updated
Aug 7, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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