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OpenTrials
Completed

NCT Number: NCT02902224

Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Completed

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Key information

Conditions

Exploratory Behavior Behavior

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Basel

Basel, Switzerland

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • right-handed
  • morbidly obese patients
  • scheduled for bariatric surgery

Exclusion criteria

  • Diabetes mellitus
  • cardiovascular disease
  • neurologic or psychiatric disorder

Treatment and study plan

tap water

Dietary Supplement

300ml tap water via nasogastric tube

Glucose

Dietary Supplement

300ml tap water with 75g glucose via nasogastric tube

Fructose

Dietary Supplement

300ml tap water with 25g fructose via nasogastric tube

Primary outcomes

  1. Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow

    Time frame: changes from baseline to one hour after treatment

Secondary outcomes

  1. Changes in plasma glucose

    Time frame: Changes from baseline to one hour after treatment

  2. Changes in plasma insulin

    Time frame: Changes from baseline to one hour after treatment

  3. Changes in Plasma GLP-1

    Time frame: Changes from baseline to one hour after treatment

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Sep 15, 2016
Registry last updated
Sep 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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