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Completed

NCT Number: NCT02255812

Taste Physiology in Healthy, Normal-weight Volunteers

Taste physiology describes five main taste qualities in humans: sweet, sour, salty, umami and bitter. The receptors found on the tongue are also found in the entire gut. The correlation of stimulation of these gut receptors and brain activity has not yet been examined. The objectives are to investigate the effect of different taste substances on i) regional brain activity and ii) satiation peptide release.

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Key information

Conditions

Exploratory Behavior Behavior

Age range

18 year–45 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital

Basel, CH-4031, Switzerland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • right-handed healthy males
  • Body-mass index of < 25
  • Age 18-45 years
  • no drugs
  • non-smoking

Exclusion criteria

  • Smoking
  • Substance abuse
  • Regular intake of medications (except for oral contraceptives)
  • Medical or psychiatric illness, especially: diabetes, pace-maker, claustrophobia
  • History of gastrointestinal disorders
  • Food allergies, glutamate intolerance
  • Body piercings that cannot be removed

Treatment and study plan

Single intragastric instillation of 200 mL tap water via nasogastric tube

Dietary Supplement

Single intragastric instillation of 2 g citric acid in 200 mL tap water via nasogastric tube

Dietary Supplement

Single intragastric instillation of 2 g salt in 200 mL tap water via nasogastric tube

Dietary Supplement

Single intragastric instillation of 0.017 g quinine in 200 mL tap water via nasogastric tube

Dietary Supplement

Single intragastric instillation of 1 g monosodium glutamate in 200 mL tap water via nasogastric tube

Dietary Supplement

Single intragastric instillation of 25 g glucose in 200 mL tap water via nasogastric tube

Dietary Supplement

Primary outcomes

  1. regional brain activity assessed by functional Magnetic Resonance Imaging (fMRI)

    Time frame: changes from baseline to one hour after treatment

    Changes in resting state functional connectivity

Secondary outcomes

  1. gastrointestinal satiation peptide secretion

    Time frame: changes from baseline to one hour after treatment

    Unit of Measure: glucagon like peptide-1 (GLP-1) in pg/mL, peptide tyrosine tyrosine (PYY) in pg/mL and gastric inhibitory polypeptide (GIP) in pg/mL

  2. glucose and insulin secretion

    Time frame: changes from baseline to one hour after treatment

    Unit of Measure: glucose in mmol/L, insulin in μU/mL

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Oct 3, 2014
Registry last updated
Oct 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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