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NCT Number: NCT07050381

The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

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Key information

Conditions

Arteriovenous Malformation of Central Nervous System Aneurysm Aneurysm Cerebral Aneurysm, Ruptured Aneurysmatic Subarachnoid Haemorrhage Arteriovenous Malformations Brain Diseases Cardiovascular Abnormalities Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Hemorrhage Intracranial Aneurysm Intracranial Arterial Diseases Intracranial Hemorrhages Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Subarachnoid Hemorrhage Vascular Diseases Vascular Malformations

Sex eligibility

All sexes

Study type

Observational

Primary location

Jiangsu Province Hospital, Nanjing, Jiangsu, China

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
  • No history of stroke, Marfan syndrome, polycystic kidney disease

Exclusion criteria

  • pAVM without flow-related aneurysms
  • Absence of clinical data

Treatment and study plan

Primary outcomes

  1. characteristics of flow-related aneurysm

    Time frame: From enrollment to the end of treatment at 8 weeks

    size ratio(aneurysm depth (mm)/parent artery diameter (mm))

Other outcomes

  1. demographic information of pAVM-rFA

    Time frame: From enrollment to the end of treatment at 8 weeks

    gender

  2. demographic information

    Time frame: From enrollment to the end of treatment at 8 weeks

    age when be hospitalized

  3. characteristics of flow-related aneurysm

    Time frame: From enrollment to the end of treatment at 8 weeks

    aspect ratio (aneurysm depth (mm)/aneurysm neck (mm))

  4. characteristic of avm

    Time frame: From enrollment to the end of treatment at 8 weeks

    avm location

  5. characteristic of avm

    Time frame: From enrollment to the end of treatment at 8 weeks

    Spetzler-Martin grade of avm

Study contacts

Contact information is provided by the study sponsor or research team.

Yifei Wang

CONTACT

[email protected]

+86-13852665323

Sponsors and collaborators

Lead sponsor

The First Affiliated Hospital with Nanjing Medical University

Other

Registry information

Official study title

Risk Factors Related to Rupture Flow-related Aneurysms in Posterior Arteriovenious Malformation: A Muti-center Observentional Research.

Acronym: pAVM-rFA

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Jul 3, 2025
Registry last updated
Jul 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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