The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome

The purpose of this study is to investigate the Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to Developmental and Molecular Factors

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Velocardiofacial Syndrome 22q11 Deletion Syndrome Abnormalities, Multiple Aortic Stenosis, Supravalvular Aortic Valve Disease Aortic Valve Stenosis Cardiovascular Abnormalities Cardiovascular Diseases Chromosome Disorders Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Craniofacial Abnormalities DiGeorge Syndrome Endocrine System Diseases Fragile X Syndrome Genetic Diseases, Inborn Genetic Diseases, X-Linked Heart Defects, Congenital Heart Diseases Heart Valve Diseases Hemic and Lymphatic Diseases Heredodegenerative Disorders, Nervous System Hypoparathyroidism Intellectual Disability Lymphatic Abnormalities Lymphatic Diseases Musculoskeletal Abnormalities Musculoskeletal Diseases Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Parathyroid Diseases Sex Chromosome Disorders Williams Syndrome X-Linked Intellectual Disability

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Schneider Children's Mediac Center of Israel

Petah Tikva, 49202, Israel

Location status: Recruiting

Location contact

Doron Gothelf, MD

CONTACT

972-03-5302663

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

chromosomal deletion proven by FISH examination

Exclusion criteria

Treatment and study plan

methylphenidate, fluoxetin, risperidone

Drug

first cognitive evaluation without methylphenidate,second cognitive evaluation with methylphenidate

Primary outcomes

Measure that are used: psychological measures, molecular tests, responsiveness to medical treatments

Time frame: 2 years

Study contacts

Contact information is provided by the study sponsor or research team.

Doron Gothelf, MD

CONTACT

[email protected]

972-03-5302663

Sponsors and collaborators

Lead sponsor

The Chaim Sheba Medical Center

Other

Registry information

Official study title

The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome (VCFS), Williams Syndrome (WS)and Fragile X Syndrome Characterization, Treatment and Examining the Connection to Developmental and Molecular Factors

Acronym: VCFS

Important dates

Study start: 2001
Primary completion: 2027
Study completion: 2027
First posted: Oct 8, 2008
Registry last updated: Mar 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed