The 'Hidden' Biological Impact of Vitamin D Deficiency: a Biomarker Study; Part 2

The investigators major aims are to: determine the vitamin D status of a group of young, apparently healthy adults in Hong Kong; examine inter-relationships between vitamin D status and biomarkers of DNA damage and repair, oxidative stress, inflammation and endothelial health; and, in part 2 of the study, investigate effects of improvement in vitamin D status on these biomarkers and other measures of well-being in those young adults shown to be deficient in vitamin D.

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Key information

Conditions

Vitamin D Deficiency Avitaminosis Deficiency Diseases Malnutrition Nutrition Disorders Nutritional and Metabolic Diseases

Age range

18 year–26 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

The Hong Kong Polytechnic University

Hong Kong, 000000

About this study

In this part 2 of the study the investigators will investigate the effect of vitamin D supplementation on biomarkers of these 'hidden' changes in apparently healthy young adults. The investigators will also explore the effect of improvement in vitamin D status in young apparently healthy adults in regard to muscular strength and response time, glucose control, a hormone that is linked to vitamin D (parathyroid hormone (PTH) ) and mood.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

apparently healthy, non-smokers
non-obese
found (in part1) to have low vitamin D status

Exclusion criteria

chronic illness
serious illness requiring medical treatment in previous 6 months
pregnancy
on regular medication or taking supplements on a regular basis

Treatment and study plan

Vitamin D

Dietary Supplement

2400 units per day for 3 months

Other names: cholecalciferol

Primary outcomes

biomarkers of oxidative stress

Time frame: 3 months

Sponsors and collaborators

Lead sponsor

The Hong Kong Polytechnic University

Other

Registry information

Official study title

The 'Hidden' Biological Impact of Vitamin D Deficiency: a Biomarker Study

Important dates

Study start: 2015
Primary completion: 2016
Study completion: 2016
First posted: May 22, 2015
Registry last updated: Jul 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed