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NCT Number: NCT06700122

Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients

Clinical Comparative Evaluation of the use of Photodynamic Therapy in conjunction with the use of Vitamin D in management Stage II Grade B Periodontitis Patients: A Randomized controlled clinical trial.

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Key information

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Marwa Helal

Cairo, 02, Egypt

About this study

This randomized clinical trial evaluates the effect of Photodynamic therapy alone with SRP versus Photodynamic therapy with SRP and Vitamin D regarding Clinical evaluation

  • Clinical attachment loss (CAL)
  • Probing pocket depth (PPD)
  • Bleeding on probing (BOP)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systemic healthy patients
  • Patients aged > 25 years
  • Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease.
  • Patients with interdental clinical attachment loss (CAL) of 3-4 mm with radiographic evidence of bone loss extending to coronal third of the root.
  • Radiographic bone loss (RBL) will be diagnosed using periapical parallel technique using 6 radiographic images for full mouth (3- radiographic images for maxillary arch and 3- radiographic images for mandibular arch) including anterior, canine region and posterior teeth at baseline for diagnosis.
  • No history of previous periodontal therapy.
  • No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs.
  • No previous periodontal surgery at involved sites.
  • Good oral hygiene and good compliance with the plaque control instructions following initial therapy.
  • Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months
  • Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders

Exclusion criteria

Patients taking Vitamin D as a nutritional supplement were excluded from the study

  • Smoking habits
  • Pregnant and lactating mothers
  • Patients who have been received periodontal surgery in the study area during the last 6 months.

Treatment and study plan

non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D

Dietary Supplement

non-surgical periodontal therapy (SRP) and Photodynamic therapy (PDT) with systemic vitamin D

Primary outcomes

  1. Clinical attachment level (CAL)

    Time frame: Day 0 - Week 6

    CAL will be measured form cemento- enamel junction (CEJ) to the depth of the pocket using UNC periodontal probe.

    • It will be recorded at 6 sites per tooth, the recorded readings will be used to generate mean values at each time point.

Secondary outcomes

  1. Probing Pocket Depth (PPD)

    Time frame: Day 0 - Week 6

    PPD will be measured form free gingival margin (FGM) to the depth of the pocket using UNC periodontal probe.

  2. Bleeding on probing (BOP)

    Time frame: Day 0- Week 6

    Assessment after 30 seconds after gentle brushing of the sulcus with a periodontal probe, measurement quadrant

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients: A Randomized Controlled Clinical Trial.

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Nov 21, 2024
Registry last updated
May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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