Poznan University of Life Sciences, ul.Wojska Polskiego 31
Poznan, Wielkopolska, 60-624, Poland
Completed
NCT Number: NCT03028649
The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes
The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.
Completed
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Notify MeKey information
Conditions
Age range
17 year–40 year
Sex eligibility
Male
Study type
Interventional
Phase
Phase 3
Primary location
About this study
The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- written consent to participate,
- male
- a current medical clearance to practice sports,
- training experience: at least 5 years,
- minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline).
Exclusion criteria
- current injury,
- any health-related contraindication,
- declared general feeling of being unwell,
- unwilling to follow the study protocol.
Treatment and study plan
β-hydroxy-β-methylbutyrate and a placebo supplementation
Dietary SupplementPrimary outcomes
-
Changes of body composition indices after HMB supplementation
Time frame: Baseline and after 12 weeks
Analysis of the fat mass and fat free mass
-
Changes of body composition indices after placebo treatment
Time frame: Baseline and after 12 weeks
Analysis of the fat mass and fat free mass
-
Changes of aerobic capacity after HMB supplementation
Time frame: Baseline and after 12 weeks
-
Changes of aerobic capacity after placebo treatment
Time frame: Baseline and after 12 weeks
-
Changes of anaerobic capacity after HMB supplementation
Time frame: Baseline and after 12 weeks
-
Changes of anaerobic capacity after placebo treatment
Time frame: Baseline and after 12 weeks
-
Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation
Time frame: Baseline and after 12 weeks
-
Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment
Time frame: Baseline and after 12 weeks
-
Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation
Time frame: Baseline and after 12 weeks
-
Changes of testosterone, cortisol and lactate levels in blood after placebo treatment
Time frame: Baseline and after 12 weeks
Secondary outcomes
-
Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass)
Time frame: 1 year
-
Statistical evaluation of the significance of differences between the changes in aerobic capacity indices
Time frame: 1 year
-
Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices
Time frame: 1 year
-
Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood
Time frame: 1 year
Sponsors and collaborators
Lead sponsor
Poznan University of Medical Sciences
Other
Collaborators
- National Science Centre, Poland
- Poznan University of Life Sciences
Registry information
Official study title
The Effect of β-hydroxy-β-methylbutyrate (HMB) Supplementation on Physical Capacity and Body Composition in Trained Athletes
Important dates
- Study start
- 2010
- Primary completion
- 2014
- Study completion
- 2014
- First posted
- Jan 23, 2017
- Registry last updated
- Jan 23, 2017
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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