The Association Between Different Markers With Development of Maternal and Neonatal Complications in Women With Severe Preeclampsia

pregnant women diagnosed with severe preeclampsia were subjected to • Full history taking including a detailed history of the hypertension state during the current pregnancy (onset, course, current medication, and whether the blood pressure is controlled or not).gravidity , parity mode of delivery any medical disorders, the presence of headache ,blurring of vision and epigastric pain.

• Complete physical examination: general (including BMI & blood pressure measurement) and obstetric examinations.
• Routine obstetric ultrasound and Doppler indices Including umbilical artery Doppler (RI).
• Laboratory investigations :

• Complete blood count (CBC). 2 albuminuria will be detected by dipstick kits . 3. Liver enzymes & kidney function. 4.PT,PC,INR.
• Pelvic-Abdominal ultrasound to assess the presence of ascites Ultrasound examination will be performed by a consultant obstetrician to detect free fluid in the peritoneal cavity, especially at hepato-renal pouch, sub-splenic area, or para-colic gutters.

The presence of ascites will be further confirmed at the time of delivery.

3-All labours will be attended by an expert neonatologist and the following will be recorded:

• APGAR score at (1 min).
• The further need for neonatal intensive care unit (NICU) admission.
• Perinatal death

Inclusion criteria

• Maternal age from 18 to 40 years.
• Gestational age (28_38) weeks, confirmed by the first day of the last menstrual period or first trimesteric ultrasound
• All suffering of severe preeclampsia

Exclusion criteria

• known liver disease
• Maternal medical disorders rather than hypertension.
• Rupture of membrane.
• Renal disorder.
• History of illicit drug use.
• Fetal congenital anomalies.
• The maternal administration of respiratory depressants within 2 hours from the delivery of the fetus (e. g., opioid analgesic )
• Associated inflammatory disease or sepsis.