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Completed

NCT Number: NCT07265336

Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women

The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.

This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.

The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.

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Key information

Conditions

Preeclampsia Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pre-Eclampsia Pregnancy Complications Severe Preeclampsia Urogenital Diseases

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Saint Thomas Hospital

Panama City, Provincia de Panamá, Panama

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Gestational age: 24-40 weeks
  • Cases: Diagnosis of severe preeclampsia
  • Control: Normal blood pressure

Exclusion criteria

  • Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).
  • Clinical conditions that could hinder the results (diarrhea, vomit)
  • Recent use of bicarbonate

Treatment and study plan

Arterial blood gases

Diagnostic Test

Determination of Excess Base in arterial blood gases before delivery / termination of pregnancy

Primary outcomes

  1. Value of excess base

    Time frame: Immediately before delivery

    Total measure of excess base measured by gasometry in an arterial blood sample

  2. Hypertensive crisis

    Time frame: From admission to day three (3) after delivery

    Elevation of the blood pressure above 160 (systolic) and 110 (diastolic).

Secondary outcomes

  1. Lactate

    Time frame: Immediately before delivery

    Concentration of lactate measured by gasometry in a sample of arterial blood.

  2. Bicarbonate

    Time frame: Immediately before delivery

    Concentration of bicarbonate measured by gasometry in arterial blood gases

Sponsors and collaborators

Lead sponsor

Saint Thomas Hospital, Panama

Other

Registry information

Official study title

Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 4, 2025
Registry last updated
Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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