Test Serum Clinical Study

Inclusion criteria

• Chinese female with 25-40 years old.
• All skin types by subjects' self-perceived.
• Willing to perform HA injection.
• Did not perform any of the beauty procedure projects in the past 6 months.
• Lack of hydration, radiance, brightness, smoothness, firmness and elasticity by self-claimed.
• Presenting with corresponding severity for the attribute evaluated by Dermatologist included:

• Radiance, smoothness, elasticity, cheek plumpness and firmness: 3≤grade≤6.
• Global fine lines: 3≤grade.
• Underneath eye wrinkles: 2≤grade≤5.
• Forehead wrinkles: 1<grade≤4.
• Glabella wrinkles: 1<grade.
• All accept not to use any cosmetics, skincare products, beauty equipment, all topical medications and cleansing products on face at visit days.
• Did not participate any clinical test or cosmetic product test on skin within 1 months.
• No disagreement of dermatologist because of other reasons that exclude the participation of the volunteer.
• In general, good health at the time of the study.
• Willing and able to participate as evidenced by signing of informed consent & photo release form.
• Must be willing to comply with all study protocol requirements.

Exclusion criteria

• Pregnant or breast-feeding woman or woman planning pregnancy during the study.
• Subject deprived of rights by a court or administrative order.
• Major subject to a guardianship order.
• Subject residing in a health or social care establishment.
• Patient in an emergency setting.
• Subject with a skin disease in the test areas as well as skin allergy (particularly e.g., acne, rosacea, eczema).
• Subject presenting a stable or progressive serious disease (per investigator's assessment).
• Immuno-compromised subject.
• Subject with history of allergy to cosmetic or personal care products or ingredients.
• Subject presenting excessive exposure to sunlight or UV radiation (investigator's assessment).
• Subject with history of sunlight sensitivity or allergies.
• Subject regularly practicing aquatic or nautical sports.
• Subject regularly attending a sauna.
• Subject with physical highly sensitive constitution.
• Subject with cardiovascular or circulatory history.
• Subject with a history of skin cancer or malignant melanoma.
• Intake of antihistamines, antibiotics, corticosteroids, non-steroidal anti-inflammatories or immune-suppressants in the last 6 months before study.