Shanghai China-norm Quality Technical Service Co., Ltd.
Shanghai, Shanghai Municipality, 200072, China
NCT Number: NCT07179263
This clinical study employs a single-center, split-face, randomized, and on-site controlled design to compare two methods for inducing skin redness (50% Glycolic Acid application and tape stripping) on the face and forearm in a minimum of 40 healthy female subjects. The study involves instrumental measurements (erythema index and a* value), photographic analysis, and expert clinical grading at multiple time points (baseline, 10min, 30min, 1h, 2h, and 4h after induction) to evaluate and compare the efficacy and response profiles of both irritation models.
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Notify Me18 year–60 year
Female
Interventional
Not applicable
Shanghai, Shanghai Municipality, 200072, China
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Subjects use 3 drops about 0.2g of 50% Glycolic Acid product on half face under instruction, then wait for 3 minutes and wash face by tap water. Wait for 10 minutes before measuring.
Technician use the D100 to paste on the center of the test area and make it fit the skin more completely and evenly by pump fully cover the D100 patch for 10 seconds. Stripping on each test area until the skin change into redness. The number of stripping will be recorded.
Time frame: From baseline to 4-hour after inducing
Time frame: From baseline to 4-hour after inducing
The a*value is a parameter in the CIELAB color space (also known as Lab) that quantifies a color's position along the red-green axis .
Time frame: From baseline to 4-hour after inducing
Time frame: From baseline to 4-hour inducing
ChinaNorm
Industry
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