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OpenTrials
Completed

NCT Number: NCT07200492

Anti-Redness Clinical Study

This clinical study is a single-center, randomized, split-face, on-site controlled trial conducted at Shanghai China-Norm Quality Technical Service Co., Ltd. The primary objective is to evaluate the efficacy of Eucerin Ultrasensitive Repair Intensive Source Serum in providing instant and long-lasting (24-hour) soothing and repairing effects under induced redness conditions. The design involves recruiting 30 healthy Chinese female subjects aged 18-60 years, who meet stringent inclusion/exclusion criteria, including absence of skin conditions and no recent participation in similar studies. Redness is induced using 50% Glycolic Acid on the entire face and tape stripping on both forearms.

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Key information

Age range

18 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Shanghai China-norm Quality Technical Service Co., Ltd.

Shanghai, Shanghai Municipality, 200072, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Chinese female whose age range from 18 to 60 years old;
  • Be in general good health and good mental state;
  • Have no any broken,scars,birthmarks and other imperfections on the test area;
  • Redness/erythema≥grade 2 after modelling inducing and the score of redness must be increased after inducing;
  • Not currently be participating in any other study involving the test area(Face and Forearm);
  • Not have participated in any other study involving the test area in the past one month;
  • Be willing to read,understand and able to sign the Informed Consent Form and Photo Release From;
  • Be willing to comply with all study protocol requirements.

Exclusion criteria

  • Intending to get pregnant, be pregnant, be lactating, be within 6 months of delivery or be unwilling to take necessary precautions to avoid a pregnancy;
  • Having used antihistamine drugs in the past 1 week or immunosuppressants in the past 1 month;
  • Taken anti-allergic drug/injections in the past 1 month;
  • Presently have allergies, allergic dermatitis or skin disease;
  • Have sensitivity or even allergy to topical products, ingredients or fragranced products;
  • Have history of allergies;
  • Have history of suffering from skin diseases (such as psoriasis, eczema, skin cancer, etc.);
  • Have used any anti-inflammatory treatment on the test area within 2 months prior to this study starting date;
  • Has a chronic medical condition that may interfere with testing (e.g., asthma, insulin-dependent diabetes, lupus, rheumatoid arthritis or other immune/auto-immune diseases);
  • Have used any scrubs or peeling product (regardless of method) or self-tanning products or oil control products in the past 3 days;
  • Have received cosmetic medical procedures on the face (such as injectable anti-wrinkle products, cosmetic surgery, tattoo removal, home light facial procedures or home use medical devices, etc.) in the past 1 month;
  • Have excessive sun exposure or ultraviolet light exposure in the past 1 month;
  • Have applied ortho-hydroxybenzoic acid, hydroquinone in the past 3 months; or used prescriptions (such as antibiotic, retinoids, alpha hydroxyl acid and steroid), oral contraceptives;
  • Avoid providing emergency contact;
  • Subjects that are not compliant with the selection criteria or not proper for participation as determined by Principal Investigator;
  • An employee of the cosmetic companies or Shanghai China-Norm Quality technical service Co., Ltd.

Treatment and study plan

Facial serum application

Other

The trained technician will apply the 0.3g-0.4g investigational products on the subject's half face.

Forearm serum application

Other

The trained technician will apply the (2mg±0.1mg)/cm² investigational products on the subject's forearm.

Primary outcomes

  1. Skin Erythema Index via Mexameter® MX 18

    Time frame: From Baseline to 24-hour after product repeat application

  2. Colorimetry (avalue) via Chromameter CM26dG *

    Time frame: from Baseline to 24-hour after product repeat application

  3. Skin Scaliness (Desquamation) via Squamescan® 850A

    Time frame: from Baseline to 24-hour after product repeat application

  4. Forearm Skin Redness (avalue) via Cross-Polarized Light Imaging *

    Time frame: From Baseline to 24-hour after product repeat application

    The a*value is a parameter in the CIELAB color space (also known as Lab) that quantifies a color's position along the red-green axis .

  5. Facial Skin Redness and Colorimetry (a* value) via VISIA-CRP Imaging

    Time frame: from Baseline to 24-hour after product repeat application

  6. Skin Surface Evenness (SEsc) via UV Video Capture and SELS Analysis

    Time frame: from Baseline to 24-hour after product repeat application

Sponsors and collaborators

Lead sponsor

ChinaNorm

Industry

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 1, 2025
Registry last updated
Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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