Survey of Current Management of Orthopaedic Complications in CMT Patients

Charcot-Marie-Tooth (CMT) disease is the most common inherited peripheral neuropathy. Foot deformities are frequent complications in CMT patients and orthopaedic surgery is often required. As yet there are no systematic studies on the management of orthopaedic complications in CMT patients and the current approach varies between centres. This study is a survey with the aim of understanding the current surgical approach to orthopaedic complications in CMT.

The target population includes orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropathies Consortium (INC).

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Key information

Conditions

Charcot-Marie-Tooth Disease Congenital Abnormalities Congenital, Hereditary, and Neonatal Diseases and Abnormalities Genetic Diseases, Inborn Hereditary Sensory and Motor Neuropathy Heredodegenerative Disorders, Nervous System Nervous System Diseases Nervous System Malformations Neurodegenerative Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Polyneuropathies

Sex eligibility

All sexes

Study type

Observational

Primary location

National Hospital for Neurology and Neurosurgery

London, WC1N 3BG, United Kingdom

About this study

The study protocol consists of a survey addressed to orthopaedic surgeons. The survey will be completed once and it includes two different scenarios of typical CMT patients (one adult and one child).

The orthopaedic surgeons will be asked which surgical procedures they would apply to each scenario:

forefoot cavus,
clawtoes and
hindfoot varus

No medications or therapeutic agents are a component of this project.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Orthopaedic surgeons who perform surgical procedures for foot deformities in CMT patients attending centres participating in the Inherited Neuropatheis Consortium (INC)
Willing to complete survey

Exclusion criteria

Does not read or speak English
Inability to provide informed consent

Treatment and study plan

Survey

Other

Primary outcomes

Procedural correlations among orthopaedic surgeons on management of foot deformities in CMT patients

Time frame: 1 day

Sponsors and collaborators

Lead sponsor

University College London Hospitals

Other

Collaborators

Carlo Besta Neurological Institute
Children's Hospital of Philadelphia
Data Management and Coordinating Center (DMCC)
Dubowitz Neuromuscular Centre
Federal, State foundation and industry support: National Institute of Health (NIH), Muscular Dystrophy Association, Charcot Marie Tooth Association
Johns Hopkins University
National Hospital for Neurology and Neurosurgery, London
National Institutes of Health (NIH)
Stanford University
Sydney Children's Hospitals Network
University of Iowa
University of Pennsylvania
University of Rochester
University of Washington
Vanderbilt University

Registry information

Official study title

Survey of Current Management of Orthopaedic Complications in Charcot Marie Tooth Disease Patients

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Dec 4, 2013
Registry last updated: Jan 30, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed