EVALUATION OF SERUM INFLAMMATORY CYTOKINE CONCENTRATION IN HEREDITARY SENSITIVOMOTOR NEUROPATHIES

Inclusion criteria

for patients:

• Patient over 18 years of age
• Patient with CMT of HNPP with genetic confirmation, or acquired acute inflammatory disease such as Guillain-Barré syndrome
• Patient able to walk alone or with a walking aid.
• Patient affiliated to a social security scheme,
• Patient who has given his consent in writing after written and oral information

Inclusion criteria

for Healthy Volunteers:

• Patient over 18 years of age
• Patient affiliated to a social security scheme,
• Patient who has given his consent in writing after written and oral information -

Exclusion criteria

• Subject protected by law under guardianship or curators, or not able to participate in a clinical study under article L. 1121-16 of the French Public Health Code;
• Subject who has participated in a clinical research study during the last 3 months where he/she was exposed to a pharmaceutical product or medical device;
• Subject who has stayed in a tropical or subtropical country during the last 3 months;
• Pregnant or breastfeeding subject for women of childbearing age;
• Subject who has been physically active for less than 10 hours;
• Subject on a particular diet for medical reasons and prescribed by a doctor or dietitian (e.g., low-calorie or cholesterol-lowering diet);
• Person who regularly consumes large amounts of alcohol, i.e. more than 50 g of pure alcohol per day (for example, more than 4 glasses of wine 150 ml, more than 4 beers 250 ml, or more than 4 glasses of 40 ml containing a strong alcohol);
• Person who has used an illicit recreational drug in the last 3 months;
• Subject who has taken an immunosuppressive or immunomodulatory drug (except for intranasal or topical corticosteroids) in the last 2 weeks, or for more than 14 consecutive days in the last 6 months;
• Subject who has been vaccinated in the last 3 months;
• Subject who received a blood transfusion or immunoglobulins in the last 3 months;
• Person reporting not having fasted for at least 10 hours;
• Person reporting human immunodeficiency virus, hepatitis B virus or hepatitis C virus ;
• Subject who has had an infectious episode in the 3 weeks preceding the visit;
• Test positive for pregnancy urine;
• Subject with severe and/or chronic and/or recurrent disease
• Subject diagnosed with cancer and not in remission for more than 5 years.
• (only for patients) Other associated peripheral nerve pathology already diagnosed (inherited neuropathy or acquired neuropathy from another etiology).
• (only for Health volunteers) Presence of functional or physical signs of involvement of the median nerves, ulnar, external Sciatica Poplitea, internal Sciatica Poplitea, sural