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Completed

NCT Number: NCT03112876

Sebum Collection and Skin Barrier Function Analysis

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

1. Young vs older healthy population 2. Atopic dermatitis vs Acne vs Healthy controls 3. Active smokers vs non-smoker controls

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Key information

Conditions

Smoking Acne Acne Vulgaris Acneiform Eruptions Aging Atopic Dermatitis Behavior Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dermatitis Dermatitis, Atopic Genetic Diseases, Inborn Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Sebaceous Gland Diseases Skin Diseases Skin Diseases, Eczematous Skin Diseases, Genetic Skin and Connective Tissue Diseases

Age range

12 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

UC Davis Department of Dermatology

Sacramento, California, 95816, United States

About this study

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Subjects that are 12 years of age or older

Exclusion criteria

  • None

Treatment and study plan

Skin Surface Lipid Collection and Skin Barrier Function

Other

All five groups will undergo the same study intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Other names: lipid profile, sebum secretion rate, skin water loss, skin hydration

Primary outcomes

  1. Lipid Profile-aging

    Time frame: 1 day

    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

  2. Lipid Profile-acne

    Time frame: 1 day

    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

  3. Lipid Profile-atopic dermatitis

    Time frame: 1 day

    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

  4. Lipid Profile-smoking

    Time frame: 1 day

    The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

Secondary outcomes

  1. Skin Barrier Function- aging

    Time frame: 1 day

    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

  2. Skin Barrier Function- acne

    Time frame: 1 day

    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

  3. Skin Barrier Function- atopic dermatitis

    Time frame: 1 day

    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

  4. Skin Barrier Function- smoking

    Time frame: 1 day

    The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

Sponsors and collaborators

Lead sponsor

University of California, Davis

Other

Registry information

Official study title

Sebum Collection for Analysis and Correlation to Sebum Production, Barrier Function, and With Cutaneous and Internal Inflammatory Disease

Acronym: Sebum

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Apr 13, 2017
Registry last updated
Apr 13, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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