Screening for Preeclampsia With Various Markers in Low-risk Pregnancy Populations

For the prediction of late-onset preeclampsia (PE) in low risk women, the investigators established a cut-off value for sFlt-1/PlGF ratio and evaluated the combination models of Elecys, second trimester uterine artery (UtA) doppler, and fetoplacental proteins for Down syndrome screening.

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Key information

Conditions

Preeclampsia Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pre-Eclampsia Pregnancy Complications Urogenital Diseases

Age range

20 year–39 year

Sex eligibility

Female

Study type

Observational

About this study

A prospective study was carried on in Cha hospital. Serum samples for Down syndrome screening were assayed to estimate pregnancy-associated plasma protein-A (PAPP-A), alpha-fetoprotein , unconjugated estriol, human chorionic gonadotrophin , and inhibin-A. Women screened for Down syndrome were offered UtA Doppler at 20-24 weeks of gestation and then collected serial serum samples for sFlt-1/PlGF ratio at two time points (24-27 and 34-37 weeks' gestation).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women considered as a potential participant in this research were patients regularly visited at the prenatal care of Cha hospital in Seoul, Korea

Exclusion criteria

early onset and cases not to measure the sFlt/PlGF ratio and other markers
twin pregnancy
Chronic hypertension
prior history of preeclampsia
pregestational diabetes mellitus
gestational diabetes mellitus
patients delivered before 35 weeks of gestation
preeclamptic patients with onset before 35 weeks of gestation
patients with body mass index 25kg/m2 or greater
maternal age 40 years older

Treatment and study plan

Primary outcomes

identification of patients at risk for late-onset preeclampsia with sFlt-1/PlGF ratio

Time frame: at delivery

Secondary outcomes

identification of patients at risk for late-onset preeclampsia with combined biochemical markers

Time frame: at delivery

Sponsors and collaborators

Lead sponsor

CHA University

Other

Registry information

Official study title

Screening Models for Early Detection of Late-onset Preeclampsia With Various Markers in Low-risk Pregnancy Populations

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Jul 25, 2012
Registry last updated: Jul 25, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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