Satiety Effects on the Neural Valuation of Food

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

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Key information

Conditions

Fasting Behavior Congenital, Hereditary, and Neonatal Diseases and Abnormalities Dyslipidemias Fed Feeding Behavior Genetic Diseases, Inborn Hypoalphalipoproteinemias Hypolipoproteinemias Lecithin Cholesterol Acyltransferase Deficiency Lipid Metabolism Disorders Lipid Metabolism, Inborn Errors Metabolic Diseases Metabolism, Inborn Errors Nutritional and Metabolic Diseases

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre for Cognitive Neuroscience scanner suite

Singapore, 169611

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Chinese ethnicity
21 to 45 years old
English as first language
Right-handed
Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
Weigh less than 100kg with an abdominal circumference of less than 120cm
Non-smoker, or only smoke occasionally (less than 5 sticks a week)
Consume less than 2 units (200 mg) of caffeine a day
Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
Habitually sleep before 1am and wake before 9am

Exclusion criteria

On a restrictive diet (e.g., vegetarian/vegan diet)
History of food allergies
History of psychiatric or neurological disorders
History of chronic medical illness
Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
Shift worker
Claustrophobic
High astigmatism (high = >2.00 diopters)
Colour-blind

Treatment and study plan

Primary outcomes

fMRI - Willingness to Pay task (BDM auction)

Time frame: Fed and fasted visits (Wks 1 & 2)

A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.
fMRI - Monetary and Food Incentive Delay task

Time frame: Fed and fasted visits (Wks 1 & 2)

A measurement of neural response to anticipating and receiving money and food rewards.

Sponsors and collaborators

Lead sponsor

Duke-NUS Graduate Medical School

Other

Collaborators

Institute for Human Development and Potential (IHDP), Singapore

Registry information

Official study title

Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety

Important dates

Study start: 2012
Primary completion: 2013
Study completion: 2014
First posted: Nov 5, 2012
Registry last updated: Aug 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed