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OpenTrials
Completed

NCT Number: NCT01149928

Role of Cord Blood Hormones and Epinephrine in the Development of Transient Tachypnea of the Newborn

In this prospective, cross-sectional study, the aim was to investigate the possible role of cord stress hormones; adrenocorticotropic hormone (ACTH), cortisol, epinephrine, sT3, sT4, and thyroid-stimulating hormone (TSH) in the development of Transient Tachypnea of the Newborn (TTN), via their modulatory effect on epithelial sodium channels and Na-K-ATPase.

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Key information

Conditions

Wet Lung Congenital, Hereditary, and Neonatal Diseases and Abnormalities Infant, Newborn, Diseases Infant, Premature, Diseases Lung Diseases Pathological Conditions, Signs and Symptoms Pulmonary Edema Respiration Disorders Respiratory Distress Syndrome Respiratory Distress Syndrome, Newborn Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Tachypnea Transient Tachypnea of the Newborn

Age range

34 week–40 week

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Gestation age > 34 weeks
  • C/S delivered infants
  • Parental consent form signed

Exclusion criteria

  • Gestation age < 34 weeks
  • Maternal conditions that compromised fetal well-being (hypertensive disorder, diabetes, chorioamnionitis)
  • Intrauterine growth retardation
  • Congenital malformations
  • Absence of parental consent

Treatment and study plan

Primary outcomes

  1. Stress response at birth, as demonstrated by cord cortisol, adrenocorticotropic hormone, epinephrine, fT3, fT4, and thyroid-stimulating hormone in late preterm and term neonates developing transient tachypnea of the newborn.

    Time frame: postnatal first 24 hours

    At birth cord blood samples and perinatal data were collected from ceseraen deliveries of late preterm and term infants. Cord stress hormones of the infants with the diagnosis of TTN and gestational age matched controls were analyzed.

Sponsors and collaborators

Lead sponsor

Ankara University

Other

Registry information

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Jun 24, 2010
Registry last updated
Jun 24, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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