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OpenTrials
Completed

NCT Number: NCT00213681

CPAP Versus Bilevel Pressure Support Ventilation in Cardiogenic Pulmonary Edema

To evaluate whether bilevel positive airway pressure more rapidly improves ventilation than continuous positive airway pressure (CPAP) in patients with acute pulmonary edema. CPAP is delivered via a simple device connected to oxygen.

Completed

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Key information

Conditions

Severe Acute Cardiogenic Pulmonary Edema Lung Diseases Pulmonary Edema Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

CHU de ROUEN

Rouen, 76031, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age > 16 yrs, acute onset of severe respiratory distress, bilateral rales and typical findings of congestion on chest radiograph
  • breathing frequency of > 30/min, SpO2 >90%, use of accessory respiratory muscles

Treatment and study plan

Boussignac CPAP - bilevel ventilation support

Device

Primary outcomes

  1. Improvement in PaCO2 at the end of ventilation

Secondary outcomes

  1. Endotracheal intubation, myocardial infarction and mortality during the first 24 hours

  2. Duration of the ventilation

  3. Blood gases, vital signs

  4. Time to transfer to medical ward

  5. Time to hospital discharge

  6. Easiness to use was evaluated by nurses

  7. Patients operational tolerance

  8. Complications of each ventilation mode

Sponsors and collaborators

Lead sponsor

University Hospital, Rouen

Other

Registry information

Official study title

CPAP Boussignac Versus Bilevel Pressure Support Ventilation in Severe Acute Cardiogenic Pulmonary Edema

Important dates

Study start
2002
Primary completion
2005
Study completion
2005
First posted
Sep 21, 2005
Registry last updated
Jun 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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