Role of ASICs in Human Inflammatory Pain

In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity, which is a major cause of pain. Indeed, many painful conditions such as ischemia, inflammation, tumor development or tissue incision are accompanied by tissue acidification. ASIC are excitatory ion channels that are expressed in neurons, including nociceptive sensory neurons. In humans, the use of amiloride, a nonspecific inhibitor of ASICs, has demonstrated their role in the perception of pain induced by subcutaneous injections of acidic solutions. ASICs thus appear as new candidates capable of mediating pain in humans. A growing number of data suggests that, in addition to protons, ASICs may also be activated by one or more endogenous compounds produced during inflammation. The purpose of this research project is to identify these compounds by testing the effects of human inflammatory exudates on ASICs activity. The discovery of such compounds would definitely validate ASICs as novel therapeutic targets for pain treatment in humans

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Key information

Conditions

Arthritis Arthritis, Gouty Arthritis, Rheumatoid Autoimmune Diseases Chondrocalcinosis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Connective Tissue Diseases Crystal Arthropathies Genetic Diseases, Inborn Gout Gouty Arthritis Immune System Diseases Joint Diseases Metabolic Diseases Metabolism, Inborn Errors Musculoskeletal Diseases Nutritional and Metabolic Diseases Osteoarthritis Purine-Pyrimidine Metabolism, Inborn Errors Rheumatic Diseases Rheumatoid Arthritis Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Service de Rhumatologie

Nice, 06000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

septic arthritis
gonarthrosis in push-inflammatory
microcrystalline arthropathies
chronic inflammatory rheumatism

Exclusion criteria

refusal to participate in the protocol

Treatment and study plan

Primary outcomes

activation or miodulation to Electrical potential of ionic channel in the synovial fluid

Time frame: 1 day

only once because it's an single ponction of sinovial fluid.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Study of the Role of Acid Sensing Ion Channels (ASICs) in Human Inflammatory Pain

Important dates

Study start: 2018
Primary completion: 2022
Study completion: 2024
First posted: Jun 4, 2013
Registry last updated: Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed