Risk Factor Analysis for Coronary Atherosclerosis Measured by MDCT

Coronary MDCT (multi-detector computed tomography) has been useful screening imaging modality for the coronary artery disease. Recently, novel adipokines and hepatokines as well as various inflammatory markers have been known as direct regulators of atherosclerosis. Therefore, the investigators examine the correlation of various metabolic risk factors including adipokines and hepatokines with coronary atherosclerosis measured by coronary MDCT in apparently healthy people.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutritional and Metabolic Diseases Vascular Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

korea University Guro Hospital

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Apparently healthy people who underwent medical routine check up in Korea Health Promotion Center.
age > 20 years

Exclusion criteria

History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
Diabetes
Stage 2 hypertension
Severe renal or hepatic disease

Treatment and study plan

Primary outcomes

relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT

Time frame: 3month

to examine the correlation of serum concentration of various adipokine such as adiponectin, resistin, A-FABP with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score

Secondary outcomes

relation of adipokines and hepatokines with coronary atherosclerosis measured by MDCT

Time frame: 3months

to examine the correlation of serum concentration of various hepatokines such as FGF-21, fetuin- A and selenoprotein P with coronary atheroslcerosis measured by MDCT as AGATSTON score, modified Gensini score
the correlation of various inflammatory markers with coronary atherosclerosis

Time frame: 3months

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Important dates

Study start: 2012
Primary completion: 2012
First posted: May 1, 2012
Registry last updated: Oct 14, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed