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OpenTrials
Completed

NCT Number: NCT03697382

Effect of Daily Steps on Fat Metabolism

Reduced ambulatory activity has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of varying levels of daily ambulation on response to a HFTT after an acute aerobic exercise bout.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Metabolic Syndrome Nutritional and Metabolic Diseases Vascular Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Texas at Austin Human Performance Laboratory

Austin, Texas, 78712, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Exclusion criteria

  • Cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
  • Respiratory problems
  • Musculoskeletal problems that prevent prolonged sitting or exercise
  • Obesity
  • Susceptibility to fainting
  • Pregnancy

Treatment and study plan

Very Low Steps

Behavioral

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Very Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Low Steps

Behavioral

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Moderate Steps

Behavioral

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Moderate Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Primary outcomes

  1. 6-Hour Plasma Triglyceride Area Under the Curve

    Time frame: 6-hours

    Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test.

Secondary outcomes

  1. 6-Hour Plasma Insulin Area Under the Curve

    Time frame: 6-hours

    Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

  2. 6-Hour Plasma Glucose Area Under the Curve

    Time frame: 6-hours

    Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test.

Sponsors and collaborators

Lead sponsor

University of Texas at Austin

Other

Registry information

Official study title

Effect of Daily Ambulatory Activity on the Responses to Acute Aerobic Exercise.

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Oct 5, 2018
Registry last updated
Sep 30, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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