Right Versus Left Thoracic Surgical Approaches for Siewert II Gastroesophageal Junction Adenocarcinoma

Inclusion criteria

• Histologically confirmed gastroesophageal adenocarcinoma;
• R0 resectable Siewert Ⅱ, cT2-3N0-3M0 (AJCC V8 TNM classification);
• Have a performance status of 0 or 1 on the ECOG Performance Scale;
• Age 18-80 years old, both men and women;
• Estimated survival ≥6 months;
• Be willing and able to provide written informed consent/assent for the trial;
• Demonstrate adequate organ function ;
• Female subject of childbearing potential should have a negative urine or serum pregnancy within 7 days before enrollment. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required;
• Have not received systemic or local treatment for esophageal cancer in the past.

Exclusion criteria

• Have a history of other malignant tumors in the past or at the same time;
• Previous upper abdominal surgery (excluding cholecystectomy);
• Bleeding, perforation and obstruction requiring emergency surgical treatment;
• Severe heart, lung, liver and kidney dysfunction, which the researcher thinks is not suitable for operation;
• Hydrothorax and ascites with clinical symptoms need therapeutic puncture or drainage;
• Participate in other clinical studies or less than 1 month from the end of the previous clinical study;
• Have a history of psychoactive drug abuse, alcoholism or drug abuse;
• Be unable or do not agree to bear the inspection and treatment expenses at their own expense;
• The researcher thinks that it should be excluded from this study.