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OpenTrials
Completed

NCT Number: NCT05583136

Restoring Neural Oscillatory Communication in Developmental Dyslexia

Developmental dyslexia (DD) is a multifactorial disorder that hampers the education of about 10% of individuals across cultures and is associated to both phonological and visual deficits. The latter have been linked to a deficit in the magnocellular-dorsal (M-D) visual stream, that has a critical role in guiding the activity of ventral visual stream areas where letters identity is extracted. Here, we will test the efficacy of transcranial alternate current stimulation (tACS) of the M-D stream combined with reading trainings in adult participants with DD, assessing the neurophysiological underpinnings of these new trainings with EEG and fMRI/DTI.

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Key information

Conditions

Developmental Dyslexia Communication Disorders Dyslexia Language Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Specific Learning Disorder

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Luca Ronconi

Milan, Italy, 20132

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patient (age between 18 and 35)
  • Official Diagnosis of Developmental Dyslexia (DD)
  • Normal or corrected-to-normal vision and hearing
  • Normal motor skills

Exclusion criteria

  • Participants that cannot sign the consent form
  • Participants unable to read or understand and correctly complete the procedures foreseen by the study
  • Participants with a diagnosis or personal history of epilepsy or patients with a positive family history of epilepsy
  • Pregnant or breastfeeding patients
  • Participants with major psychiatric or neurological disorders and/or currently in psychopharmacological treatments.
  • Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants.
  • Participants with claustrophobia (only for fMRI)

Treatment and study plan

Parietal tACS combined with visuo-attentional training

Device

Parietal tACS combined with visuo-attentional training

Sham (placebo) tACS combined with visuo-attentional training

Device

Sham (placebo) tACS combined with visuo-attentional training

Sham (placebo) tACS combined with phonics training

Device

Sham (placebo) tACS combined with phonics training

Primary outcomes

  1. Reading score

    Time frame: Pre-training, 1-7 days post-training, follow-up at 1 and 6 months

    Text, word and pseudowords reading score

Sponsors and collaborators

Lead sponsor

IRCCS Ospedale San Raffaele

Other

Registry information

Official study title

Restoring Neural Oscillatory Communication Between Dorsal and Ventral Visual Streams in Developmental Dyslexia

Important dates

Study start
2021
Primary completion
2024
Study completion
2024
First posted
Oct 17, 2022
Registry last updated
Jan 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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