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Completed

NCT Number: NCT00254644

Morphofunctional Imaging and Developmental Dyslexia

Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.

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Key information

Conditions

Developmental Dyslexia Behavior Communication Communication Disorders Dyslexia Language Language Disorders Learning Disabilities Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurodevelopmental Disorders Neurologic Manifestations Pathological Conditions, Signs and Symptoms Signs and Symptoms Specific Learning Disorder

Age range

18 year–35 year

Sex eligibility

Male

Study type

Observational

Primary location

CHU

Tours, 37044, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Developmental dyslexia according to Critchley.
  • Normal performance intelligence quotient (PIQ)
  • Age: 18-35 years
  • Sex: Male
  • Right handed
  • No hearing deficit.

Exclusion criteria

  • No head injury
  • No attention deficit hyperactivity disorder (ADHD)

Treatment and study plan

Morphological and functional MRI

Procedure

one time

Primary outcomes

  1. Cortical thickness

    Time frame: 2 years

    The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages

Secondary outcomes

  1. Average cortical thickness

    Time frame: 2 years

    For each group, cortical thickness maps of average left and right hemispheres are compared. This will identify whether there is an asymmetry left / right in terms of cortical thickness in normal subjects and dyslexic.

Sponsors and collaborators

Lead sponsor

University Hospital, Tours

Other

Registry information

Acronym: PHR04-CH/DYS

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Nov 16, 2005
Registry last updated
Jan 16, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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