Respiratory Function and Walking Capacity in Multiple Sclerosis

Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS. This leads to increased morbidity and mortality in late stages of the disease. It is possible that respiratory dysfunction influence physical fitness in earlier stages as well. Walking disability and fatigue causes significant impact on health in patients with MS, even in earlier stages.

The hypothesis is that there is a relationship between respiratory function, walking capacity and fatigue and that daily deep breathing exercise during two months will improve respiratory function, walking capacity and fatigue.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Difficulty Walking Fatigue Immune System Diseases Mobility Limitation Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases Respiratory; Disorder, Functional, Impaired Signs and Symptoms

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Presented above.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inhabitant in Orebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval ≥ 3.0 - ≤ 7.0.
Participants must understand verbal and written information and must be relapse free ≥ 3 months prior to inclusion.

Exclusion criteria

Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction.

Treatment and study plan

Breathing exercises

Other

Breathing exercises with positive expiratory pressure.

Primary outcomes

Respiratory muscle strength

Time frame: Two months

Maximum expiratory pressure

Sponsors and collaborators

Lead sponsor

Region Örebro County

Other

Collaborators

Örebro County Council

Registry information

Important dates

Study start: 2012
Primary completion: 2014
Study completion: 2014
First posted: Jan 23, 2013
Registry last updated: Jan 18, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed