Relative Sarcopenia and Cardiometabolic Risk in Young Adults With Obesity

The goal of this research study is to learn more about the hormones that muscles make during exercise, and if those hormones are associated with type 2 diabetes risk in adults who are overweight or obese. Participants will undergo exercise testing on an upright bicycle, with blood samples taken for muscle hormones before and after exercise. The hypothesis is that adults with overweight/obesity and insulin resistance will have an impaired muscle hormone profile in response to exercise compared to adults with overweight/obesity who are not insulin resistant.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Overweight and Obesity Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Previously enrolled in protocol 2004P000013 or protocol 2012P002276, which had overweight or obesity as inclusion criteria
Ability to walk up 3 flights of stairs and 3 city blocks (to ensure ability to complete exercise testing)

Exclusion criteria

Unstable heart or lung disease
Exercise >150 minutes/week
Participation in college sports

Treatment and study plan

cardiopulmonary exercise test (CPET)

Procedure

CPET studies will be performed in the Cardiovascular Performance Program exercise lab at MGH. Subjects will undergo CPET on an upright cycle ergometer with continual measurement of metabolic gas exchange via a commercially available metabolic cart as well as heart rate and blood pressure. Exercise will proceed according to a maximal effort clinical protocol. Subjects will then undergo a standardized 30-min work load on the upright cycle ergometer based on the results of the maximal effort clinical protocol.

Primary outcomes

Percent Change in Serum Myostatin Levels From Pre- to 3 Hours Post-exercise

Time frame: Pre- to 3 hours post-exercise

Percent change in serum myostatin levels from pre- to 3 hours post-cardiopulmonary exercise test

Secondary outcomes

Percent Change in Serum Myostatin Levels From Pre- to 2 Hours Post-exercise

Time frame: Pre- to 2 hours post-exercise

Percent change in serum myostatin levels from pre- to 2 hours post-cardiopulmonary exercise test
Percent Change in Serum Myostatin Levels From Immediately Post to 2 Hours Post-exercise

Time frame: Immediately post to 2 hours post-exercise

Percent change in serum myostatin levels from immediately post to 2 hours post-cardiopulmonary exercise test

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2021
Study completion: 2021
First posted: Dec 11, 2019
Registry last updated: Jan 30, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed