Mitochondrial Remodeling After Exercise

Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

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Key information

Conditions

Overweight and Obesity Behavior Body Weight Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Disease Metabolic Diseases Mitochondrial Metabolism Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Sedentary Behavior Sedentary Lifestyle Signs and Symptoms

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Oregon State University

Corvallis, Oregon, 97331, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 18-45 years
Body mass index (BMI) 18-45 kg/m2
Sedentary (<1 hour of planned exercise per week)

Exclusion criteria

Regular exercise (>1 hour of planned exercise per week)
Smoking, tobacco or nicotine use within the last 1-year
Fasting glucose >126mg/dL
Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
Chronic metabolic or cardiovascular health conditions
Pregnant, nursing, irregular menses or post-menopausal
Lidocaine allergy
Certain medications
Physical limitations that prevent safe or successful exercise completion
Diminished capacity for consent

Treatment and study plan

Short-term Exercise Training

Behavioral

Participants will perform 2-weeks of supervised exercise training on a stationary bike.

Primary outcomes

Change in skeletal muscle mitochondrial protein degradation peptide products

Time frame: After 2-weeks of exercise training compared with before training.

Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.

Sponsors and collaborators

Lead sponsor

Oregon State University

Other

Registry information

Important dates

Study start: 2019
Primary completion: 2020
Study completion: 2022
First posted: Sep 25, 2019
Registry last updated: Feb 13, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed