Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07065747

Quantification & Classification of Inflammatory Cells in Uveitis Using OCT

The goal of this study is to determine if it's possible to use a high resolution imaging device called optical coherence tomography (OCT) to develop an unbiased, standard method of counting and categorizing the various types of cells and proteins found in an eye condition called anterior uveitis. Anterior uveitis is a type of inflammation in the eye that can be caused by many different diseases of the body.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Anterior Uveitis (AU) Arthritis Arthritis, Juvenile Autoimmune Diseases Behcet Disease Behcet Syndrome Birdshot Chorioretinitis Birdshot Chorioretinopathy Bone Diseases Cardiovascular Diseases Chorioretinitis Choroid Diseases Choroiditis Congenital, Hereditary, and Neonatal Diseases and Abnormalities Connective Tissue Diseases DNA Virus Infections Eye Diseases Genetic Diseases, Inborn Hemic and Lymphatic Diseases Hereditary Autoinflammatory Diseases Herpes Simplex Herpes Simplex Virus Herpesviridae Infections Hypersensitivity Hypersensitivity, Delayed Immune System Diseases Infections Joint Diseases Juvenile Idiopathic Arthritis (JIA) Lymphatic Diseases Lymphoproliferative Disorders Mouth Diseases Musculoskeletal Diseases Panuveitis Posterior Vitreous Detachment Retinal Diseases Retinitis Rheumatic Diseases Sarcoidosis Skin Diseases Skin Diseases, Genetic Skin Diseases, Infectious Skin Diseases, Vascular Skin Diseases, Viral Skin and Connective Tissue Diseases Spinal Diseases Spondylarthritis Spondylitis Spondyloarthritis (SA) Stomatognathic Diseases Uveal Diseases Uveitis Uveitis, Anterior Uveitis, Posterior Vascular Diseases Vasculitis Virus Diseases Vitreous Detachment White Dot Syndromes

Age range

5 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Casey Eye Institute - Oregon Health & Science University

Portland, Oregon, 97239, United States

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Uveitis Group: Eyes with active intraocular inflammation and a clinical diagnose of spondyloarthritis/HLA-B27 associated anterior uveitis, Juvenile Idiopathic Arthritis (JIA) associated chronic anterior uveitis, Herpes Simplex Virus (HSV) anterior uveitis, Birdshot chorioretinitis, Behcet disease uveitis, sarcoidosis associated uveitis, uveitis of any additional type, or uveitis masquerade.
  • Posterior Vitreous Detachment Group: Eyes with vitreous floaters and posterior vitreous detachment (PVD).
  • Healthy/Control Group: Healthy eyes with no history of uveitis, PVD, or previous eye surgery.

Exclusion criteria

  • Inability to give informed consent.
  • Inability to maintain stable fixation for OCT imaging.
  • Inability to commit to required visits to complete the study.
  • Pregnancy and breastfeeding.

Treatment and study plan

Primary outcomes

  1. Identification & Measurement of Anterior Chamber Cells

    Time frame: Day 1

    Anterior Chamber (AC) cells will be identified from OCT images by computer algorithms. AC cell number counted by OCT will be correlated with slit lamp grading. Cell size & other characteristics identified from OCT images will be associated with different uveitis diagnostic categories. The Standardization of Uveitis Nomenclature (SUN) grading system (scale: 0 = none to 4+ = severe) will be used to compare OCT-derived quantification against slit-lamp grading performed by attending physicians.

Secondary outcomes

  1. Measure of AC Flare

    Time frame: Day 1

    OCT signal of the aqueous humor will be analyzed and correlated with slit lamp grading by the attending physician. The SUN grading system (scale: 0 to 4+) will be used.

  2. Measure of Keratic Precipitates

    Time frame: Day 1

    Keratic precipitates (KPs) will be identified from OCT images. The size of the KPs will be compared across different uveitis diagnostic categories. There is no formal grading system for KPs. The investigators will use the typical qualitative assessments of morphology, distribution, and density. For morphology, cells will be described as fine, mutton-fat, stellate, or pigmented. Distribution patterns will be described as Arlt's Triangle, diffuse, central, or ring-shaped. Density will be described as few, moderate, or numerous.

  3. Measure of Vitreous Cells

    Time frame: Day 1

    Vitreous cells will be identified from OCT images. Counting of vitreous cells will be done by computer algorithms. Since vitreous cells are not formally graded or quantified in the SUN system, physician grading will be described as rare, few, moderate, numerous, or sheets and compared against the OCT-derived measurements.

  4. Measurement of Vitreous Haze

    Time frame: Day 1

    OCT signal of the vitreous clarity will be compared against clinical grading of vitreous haze. The National Eye Institute (NEI) Grading Scale will be used. Grading will be documented on a scale of 0 = no haze to 4+ = severe haze.

Study contacts

Contact information is provided by the study sponsor or research team.

Denzil Romfh, OD

CONTACT

[email protected]

503-494-4351

Humberto Martinez, COT, MBA

CONTACT

[email protected]

503-494-7712

Sponsors and collaborators

Lead sponsor

Oregon Health and Science University

Other

Collaborators

  • National Eye Institute (NEI)

Registry information

Official study title

Objective Grading of Intraocular Inflammation in Uveitis Using Optical Coherence Tomography

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jul 15, 2025
Registry last updated
Jul 17, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.