Rheumatology Patient Registry and Biore… | Clinical Trial

Key information

Conditions

Rheumatic Diseases Adult Onset Still Disease Ankylosing Spondylitis Ankylosis Antiphospholipid Syndrome Arteritis Arthritis Arthritis, Infectious Arthritis, Psoriatic Arthritis, Reactive Arthritis, Rheumatoid Autoimmune Diseases Autoimmune Diseases of the Nervous System Axial Spondyloarthritis Bacterial Infections Bacterial Infections and Mycoses Behcet Disease Behcet Syndrome Bone Diseases Borrelia Infections Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Chronic Disease Congenital, Hereditary, and Neonatal Diseases and Abnormalities Connective Tissue Diseases Dermatomyositis Disease Attributes Dry Eye Syndromes Eye Diseases Genetic Diseases, Inborn Giant Cell Arteritis Gram-Negative Bacterial Infections Hemic and Lymphatic Diseases Hereditary Autoinflammatory Diseases Hypersensitivity Hypersensitivity, Delayed Immune System Diseases Infections Joint Diseases Lacrimal Apparatus Diseases Lupus Erythematosus, Systemic Lyme Disease Lymphatic Diseases Lymphoproliferative Disorders Mixed Connective Tissue Disease Mouth Diseases Muscular Diseases Musculoskeletal Diseases Myositis Nervous System Diseases Neuromuscular Diseases Panuveitis Pathologic Processes Pathological Conditions, Signs and Symptoms Polymyalgia Rheumatica Polymyositis Post-Infectious Disorders Psoriasis Psoriatic Arthritis Reactive Arthritis Rheumatoid Arthritis Salivary Gland Diseases Sarcoidosis Scleroderma Scleroderma, Diffuse Scleroderma, Systemic Sjogren's Syndrome Skin Diseases Skin Diseases, Genetic Skin Diseases, Papulosquamous Skin Diseases, Vascular Skin and Connective Tissue Diseases Spinal Diseases Spirochaetales Infections Spondylarthritis Spondylarthropathies Spondylitis Spondylitis, Ankylosing Still's Disease, Adult-Onset Stomatognathic Diseases Systemic Lupus Erythematosus Systemic Sclerosis Tick-Borne Diseases Undifferentiated Connective Tissue Diseases Uveal Diseases Uveitis Uveitis, Anterior Vascular Diseases Vasculitis Vasculitis, Central Nervous System Vector Borne Diseases Xerostomia

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Yale New Haven Hospital

New Haven, Connecticut, 06510, United States

Location status: Recruiting

Location contact

Monique Hinchcliff, MD

PRINCIPAL_INVESTIGATOR

CONTACT

203-737-5571

About this study

A rheumatology biorepository will be created to permit comparative analyses between the rheumatic diseases in order to increase the understanding of disease pathogenesis. Patients seen at Yale clinics diagnosed with rheumatic diseases are invited to participate in this study. These rheumatic diseases include, but are not limited to: adult onset Still's disease, ankylosing spondylitis, psoriatic arthritis, reactive arthritis, antiphospholipid syndrome, systemic lupus erythematosus, Behcet's disease, dermatomyositis, polymyositis, giant cell arteritis and other vasculitides, Lyme's disease, mixed connective tissue disease, polymyalgia rheumatica, rheumatoid arthritis, sarcoidosis, systemic sclerosis (scleroderma), Sjogren's syndrome, and undifferentiated connective tissue disease.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for Rheumatology Patients:

Patients ≥18 years old with a diagnosis of a rheumatic autoimmune disease including, but not limited to: adult onset Still's disease, ankylosing spondylitis, antiphospholipid syndrome, Behcet's disease, dermatomyositis, giant cell arteritis, mixed connective tissue disease, polymyalgia rheumatica, polymyositis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, sarcoidosis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus, undifferentiated connective tissue disease and vasculitis.
Receiving clinical care at Yale Rheumatology clinics

Exclusion criteria

for Rheumatology Patients:

Unable to provide informed consent
No patients will be excluded based on gender or ethnicity or pregnancy status.
Women who are currently pregnant will need to wait to donate a skin biopsy until after they deliver.
Patients allergic to lidocaine or epinephrine or have a history of impaired wound healing will not be able to donate a skin biopsy.

Inclusion criteria

for Healthy Volunteers:

Age ≥ 18 years old
No chronic skin conditions
No diagnosis of a rheumatic autoimmune disease (e.g., lupus, rheumatoid arthritis)
Normal BMI

Exclusion criteria

for Healthy Volunteers:

Unable to provide informed consent.
Currently pregnant or nursing unless the study goal is to study pregnant or nursing woman.
Allergies to lidocaine or epinephrine (skin biopsies).
A history of impaired wound healing (skin biopsies).

Treatment and study plan

Primary outcomes

Correlate outcomes and biomarkers of rheumatic diseases

Time frame: 10 years

Evaluate clinical data and biospecimens to correlate outcomes and biomarkers of rheumatic diseases.

Study contacts

Contact information is provided by the study sponsor or research team.

Stephanie Perez, MS, BS

CONTACT

[email protected]

203-737-5571

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

Rheumatology Research Foundation

Registry information

Important dates

Study start: 2020
Primary completion: 2030
Study completion: 2030
First posted: May 26, 2020
Registry last updated: Feb 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed