PUER ("Previously Unrecognized Emerging Risks") Life Clinical Study

The two key elements of the PUER Research protocol include (1) molecular and laboratory profiling and (2) non-invasive imaging and wearables/ "quantified self" measurements. All elements are optional. Molecular assessments will be conducted using peripheral blood samples, and potentially urine, stool or saliva samples. Non-invasive imaging assessment will consist of magnetic resonance imaging (MRI) and computerized tomography (CT) scans, ultrasound, and x-ray. All imaging modalities are optional. Other functional assessments, including respiratory, cardiac and other functions, as well as self-quantifiable assessments via wearables, may also be conducted and are optional.

The study will result in longitudinal data collection to inform if any modalities employed here can inform of baseline deviations for individuals. Researchers at study sites will not be blinded to the data being collected during this study.

Inclusion criteria

• Male or non-pregnant female; age 18 to 90
• Absence or presence of any medical history or any signs or symptoms of any disease
• Women of childbearing potential (WOCBP) must have a negative urine pregnancy test (UPT) at all visits

Exclusion criteria

• Unwillingness or inability to participate in the study
• Unwillingness or inability to provide written Informed Consent Form
• WOCBP with positive pregnancy test at enrollment or at any visit