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OpenTrials
Enrolling by Invitation

NCT Number: NCT06444594

Transient Receptor Potential Channels

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

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Key information

Conditions

Aging

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Noll Laboratory

University Park, Pennsylvania, 16802, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 18-85 years old.
  • Women will not be pregnant and/or breastfeeding.

Exclusion criteria

  • Currently pregnant or breastfeeding
  • Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime)
  • Known skin allergies or current rash, skin disease, disorders of pigmentation
  • Diabetes
  • Body mass index >35kg*m-2
  • Using calcium channel blockers
  • Raynaud's syndrome
  • Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive
  • Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin

Treatment and study plan

TRPM8 Agonist

Drug

menthol gel 4-10%

Other names: menthol

TRPV1 Agonist

Drug

camphor gel 5-20%

Other names: camphor

TRPV4 Agonist

Drug

capsaicin gel 0.05-1%%

Other names: capsaicin

TRPM8, TRPV4, TRPV1 Agonists

Drug

menthol (4-10%), capsaicin (0.05-1%), camphor (5-20%)

Other names: menthol, capsaicin, camphor

Vehicle gel

Other

Inactive vehicle gel

Other names: Inactive vehicle gel

Primary outcomes

  1. Skin blood flow during slow local heating

    Time frame: 75 minutes

    Laser doppler flowmeter to measure skin blood flow during a slow local heating of the skin

  2. Somatosensory perception

    Time frame: every 5 minutes for 120 minues

    heat and cold perception using a visual analog scale

  3. algometer measurement

    Time frame: every 30 minutes for 120 minutes

    pain pressure thresholds

Sponsors and collaborators

Lead sponsor

Penn State University

Other

Registry information

Official study title

Transient Receptor Potential Channels in Human Skin

Acronym: TRP

Important dates

Study start
2024
Primary completion
2026
Study completion
2027
First posted
Jun 5, 2024
Registry last updated
Jul 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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