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OpenTrials
Completed

NCT Number: NCT02478801

Protein Requirements in Endurance-trained Athlete

Protein requirements in individuals who participate in endurance-based exercise training have been suggested to be greater than the current recommended dietary allowance (RDA).

Nutritional requirements for dietary amino acids in adults have traditionally been determined utilizing the nitrogen balance technique, which is prone to underestimating protein requirements. As a result, there is a need to re-evaluate recommendations in order to characterize how dietary amino acid needs may be modulated by physical activity.

Recent studies using the minimally invasive indicator amino acid oxidation (IAAO) technique have suggested that protein requirements in young men are at least 50% higher than RDA based on nitrogen balance data.

Therefore, the purpose of this study is to measure the protein requirement in endurance trained adults using the IAAO technique.

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Key information

Conditions

Increased Metabolic Requirement Healthy

Age range

18 year–35 year

Sex eligibility

Male

Study type

Interventional

Phase

Early Phase 1

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy, male, endurance-trained participants who regularly more than 40 km/week
  • Ability to perform the exercise stimulus (20 km run) on metabolic trial.

Exclusion criteria

  • Inability to meet health and physical activity guidelines according to the physical activity readiness questionnaire (PAR-Q+)
  • Inability to adhere to any of the protocol guidelines (i.e. alcohol, caffeine consumption)
  • Regular tobacco use
  • Illicit drug use

Treatment and study plan

amino acids intake

Dietary Supplement

amino acids intakes will be varied at 0.2-2.8 g/kg/day

Primary outcomes

  1. 13CO2 (carbon dioxide) excretion (μmol/kg/h)

    Time frame: 4 hours / study day

Secondary outcomes

  1. [13C]phenylalanine oxidation (μmol/kg/h)

    Time frame: 4 hours/study day

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Ajinomoto Co., Inc.

Registry information

Official study title

Evaluation of Protein Requirements in Male Endurance Athletes

Acronym: EP

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Jun 23, 2015
Registry last updated
Jun 16, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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