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OpenTrials
Completed

NCT Number: NCT03147001

Protein Ingestion Before Training Low

A randomized interventions study using a crossover design. Ten well trained triathletes or bikeriders will be included for to undergo two trail separated by about 3 weeks. The night before the trail each subject will performe a high intense interval trainings session on an ergometer bike. during the night an infusion of aminoacid tracers will be initiated. The subject is woken at 6.30 a.m. Blood samples and a musclebiopsy will be collected prior to the morning bike ride at 8.00a.m. Immediately before the morning bike ride is started the subject will ingest a drink of 0,5g protein or a non-caloric placebo (random order). During the bike ride and the following 4,5 hours blood will be drawn with regular intervals. at time point 0, 60 and 180 min after the training session biopsies are collected.

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Key information

Conditions

Protein Metabolism

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy well-trained triathletes or cyclists
  • VO2max > 55 ml O2/kg/min
  • Training and has been training more than 7 times a week the last 6 months.

Exclusion criteria

  • VO2max < 55 ml O2/kg/min
  • Has chronic disease
  • has incjected with tracer on a previous occasion.

Treatment and study plan

Protein ingestion

Other

A protein drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).

Non-caloric placebo ingestion

Other

A placebo drink was ingested prior to the 90min bike ride in one of the completed trails (order randomised).

Primary outcomes

  1. Muscle protein fractional synthetic rate (FSR)

    Time frame: FSR was measure over at time period of six hours

Secondary outcomes

  1. Tracer kinetics dilution model

    Time frame: six hours

    A-V tracer dilution model was applied across the forearm.

  2. Muscle signalling

    Time frame: Determined in biopsies sampled before and immediatly after 90min exercise in addition to one and four hours after exercise.

    Muscle signalling will be determined using western blotting in each muscle biopsy

  3. Nitrogen excretion

    Time frame: Urine is collected during two periods. Collection period one: 12 hours prior to morning exercise. Collection period 2: During and four hours following exercise. Blood samples is drawn repeatedly from before to four hours after exercise.

    nitrogen excretion is determined by Plasma and urinary carbide analysis as well as plasma NH4+.

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

  • Arla Foods
  • Innovation Fund Denmark
  • Team Denmark

Registry information

Official study title

Nutritional Strategies for Optimizing Adaptations and Recovery Following Training 'Low'.

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
May 10, 2017
Registry last updated
May 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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