Progressive Strength Training in Spinal Muscular Atrophy

The proposed feasibility study is necessary to test if children and young adults will participate in and adhere to a 12-week, home-based, supervised progressive strength training exercise program and to obtain preliminary data that will subsequently allow us to determine the safety and impact of strength training in spinal muscular atrophy. Our pilot study will address 3 aims: (1) Ascertain the feasibility of, and potential barriers to, participation in and adherence to a 12-week home-based, supervised, progressive strength training exercise program in children and young adults aged 5-21 years with SMA types II and III; (2) Determine the safety and tolerability of progressive strength training in a pilot study sample of children and young adults with SMA types II and III; and (3) Determine candidate outcome measures.

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Key information

Conditions

Muscular Atrophy, Spinal Central Nervous System Diseases Motor Neuron Disease Nervous System Diseases Neurodegenerative Diseases Neuromuscular Diseases Spinal Cord Diseases

Age range

5 year–21 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Utah

Salt Lake City, Utah, 84132, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age 5-21 years
diagnosis of SMA type II or III
at least antigravity strength in elbow flexors
ability to follow commands and stay on task
place of residence within a 60-minute or 60-mile drive of the University of Utah

Exclusion criteria

planned surgery or out-of-town trips during the proposed intervention period
inability to travel to study center for testing
neurological diagnosis other than SMA

Treatment and study plan

Progressive strength training

Other

the systematic increase in resistance weights

Primary outcomes

Strength

Time frame: 12 weeks

Primary Outcome Measure was muscle strength. Strength was measured using a fixed myometry evaluation, quantitative muscle analysis (QMA). QMA utilizes a relative fixed point for the participant to exert effort. Each muscle of interest was tested using QMA.

Sponsors and collaborators

Lead sponsor

University of Utah

Other

Registry information

Official study title

Pilot Study of Progressive Strength Training in Spinal Muscular Atrophy

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: Nov 3, 2010
Registry last updated: Jun 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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