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Completed

NCT Number: NCT03102905

Prevalence of Replication of Human Herpes Virus 6 (HHV6) in Blood and Skin During Exanthemia, in Patients With Hemopathy. Is There a Correlation With the Etiology of the Exanthema?

To look for the replication of HHV6 by PCR in the skin, in these patients with haemopathies presenting an exanthema. This will make it possible to evaluate the prevalence of the positivity of this PCR in the skin. Then the investigator can investigate whether there is an association between the positivity of HHV6 PCR in the blood and / or skin and the viral etiology of the exanthema. If this association exists, it will make it possible to improve the diagnosis in the context of the exanthema and thus to improve the therapeutic management of these patients.

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Key information

Conditions

HHV6 Exanthema Hemopathy Skin Diseases Skin and Connective Tissue Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens Picardie

Amiens, Picardie, 80054, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Supported for any type of hemopathy.
  • Allograft, autografted or ungrafted haematopoietic stem cells
  • Having presented an exanthema during hospitalization, for which a cutaneous biopsy had been performed
  • Having had a blood test of the HHV6 virus by PCR at least within the previous 40 days or following the rash.
  • Age greater than or equal to 18 years
  • Patient informed of the protocol by post, not having refused within one month of sending the said courier.

Exclusion criteria

  • Patient who refused the search.
  • Patient whose HHV6 PCR in the blood was carried out at a distance of more than 40 days from the skin biopsy.

Treatment and study plan

Measurement of the prevalence of the positivity of cutaneous HHV6 quantitative PCR in the cohort studied.

Other

To evaluate the prevalence of the positivity of HHV6 PCR in the skin, during the exanthema in patients hospitalized for haemopathy.

Primary outcomes

  1. Measurement of the prevalence of the positivity of cutaneous HHV6 quantitative PCR in the cohort studied.

    Time frame: 1 day

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Acronym: REPLIPO

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Apr 6, 2017
Registry last updated
Jun 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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