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Completed

NCT Number: NCT03807791

Study of Prevalence and Risk Factors of Hypovitaminosis C in Long Term Care Unit

The clinical finding of skin rashes which appear after a vitamin C deficiency in Long Term Care Unit leads us to believe that the institutional diet could predispose to this kind of deficiency. Vitamin C has a key role into the struggle against oxidant stress and is involved into the connective tissue formation of the skin and the vascular endothelium. Vitamin C deficiency affects currently 15 to 25% of the elderly over 65 years old reaching 15% women and 20% men after 65 according to Johnston and Al. It concerns mainly the people in precarious situations (persons without fixed homes, ethyl-smoking persons) and elderly over 65 years. Hypovitaminosis C, defined by plasma level between 5 mg/L and 15 mg/L (28.41 to 85.23 µmol/L), is currently undiagnosed, especially with people with a risk of food deficiency and its prevalence increases with age. The treatment consists of a daily oral supplementation of 1 gram of vitamin C/d for 15 days. A minimum intake of 10 mg/D of vitamin C is required to prevent scurvy and maintain a total pool of 350 mg. A diet modification by a systematic intake of 2 glasses of fresh orange juice and/or the consumption of raw fruits and vegetables would prevent the appearance of scurvy.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Unité de soins Longue Durée, Hôpital Pierre Garraud (Hospices Civils de Lyon)

Lyon, 69005, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female over 65 years old
  • living in the Unit of Long Term Care without any limit time.
  • with a system of social insurance
  • Who gave its consent by his own , or with help of his representant or his tutor or curator.

Exclusion criteria

  • rejection of the blood sample
  • patient feeding with articial nutritional feeding (stomach tube feeding)
  • person close to death, who is not able to feed himself and / or with life-threatening in short time.
  • Patient with personal history of vitamin C deficiency.

Treatment and study plan

Blood sample

Procedure

A blood sample will be taken by the nurse of our unit within a week after their consent. It consists as a simple blood sample and it will be taken during the normal analysis planed by the chief of the service in order to avoid to collect two different samples.

The measurement method will use equipment from the Lyon Sud hospital laboratory. The samples need a pre-treatment in the 3 hours after taking the blood to avoid the oxidation of vitamin C and a result lower than expected.

Primary outcomes

  1. Vitamin C plasma level

    Time frame: Between day 0 and day 7.

    • ) Collection of the consent
    • ) At the same time as other analysis for current cares a blood sample taken by a nurse of our unit to determine plasma levels of vitamin C.
    • ) Registration of risk factors of vitamin C deficiency. .
    • ) Doing a clinical exam within 7 days after the blood sample.

Secondary outcomes

  1. Supposed risk factors of hypovitaminosis C

    Time frame: Day 0

    The supposed risk factors are represent by general risk factors, Anthropometric parameters, Nutritional risk factors, Risk factors because of Unit of Long Term Care, Pathologies associated, Clinical signs associated with vitamin C deficiency

  2. Cutaneous symptoms

    Time frame: Day 0

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: Vitamin C

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jan 17, 2019
Registry last updated
Sep 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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