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OpenTrials
Completed

NCT Number: NCT06027476

Preoperative Inflammatory Status and Postoperative Acute Kidney Injury

Acute kidney injury (AKI) is a common complication during the early postoperative period after noncardiac surgery. Patients with AKI are at an increased risk of developing chronic kidney disease, prolonging hospitalization, and experiencing higher rates of morbidity and mortality. Identifying preoperative risk factors for postoperative AKI can significantly contribute to the development of preventive strategies and improved perioperative care in this vulnerable patient population.

The goal of this retrospective study is to investigate the predictive value of preoperative inflammatory status, as measured by complete blood count-derived inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), derived neutrophil-to-lymphocyte ratio (dNLR), neutrophil-to-lymphocyte*platelet ratio (NLPR), systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), and aggregate index of systemic inflammation (AISI), on postoperative AKI in elderly patients undergoing non-cardiac surgery.

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Key information

Conditions

Postoperative Acute Kidney Injury

Age range

65 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Rao Sun

Wuhan, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged ≥ 65 years.
  • general, gynaecological, neurosurgery, orthopaedic, or thoracic surgery.
  • surgery duration lasting longer than one hour.

Exclusion criteria

  • patients with an American Society of Anesthesiologists (ASA) physical status V.
  • those with concurrent cardiac, vascular, transplant or urological surgeries.
  • those with end-stage renal disease (i.e. a glomerular filtration rate of 15 mL/min/1.73 m2 or receiving haemodialysis) or a history of kidney transplantation..
  • those did not have sufficient data required for calculation for inflammatory markers or AKI evaluation.

Treatment and study plan

Primary outcomes

  1. Number of participants with acute kidney injury after surgery

    Time frame: Within 7 days after surgery

    In accordance with the KDIGO creatinine criteria: a serum creatinine increases of 26.5 mmol/L within 48 hours or 1.5 times baseline within 7 days after surgery.

Sponsors and collaborators

Lead sponsor

Rao Sun

Other

Registry information

Official study title

Prognostic Significance of Preoperative Inflammatory Status for Postoperative Acute Kidney Injury in Elderly Patients Undergoing Non-cardiac Surgery

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Sep 7, 2023
Registry last updated
Nov 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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