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Completed

NCT Number: NCT06598228

Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation

Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality. The recovery mode of kidney injury after PLT has not been systematically studied. Therefore, in this study the investigators aimed to systematically evaluate prognosis of AKI after PLT, combine the recovery mode of AKI with related risk factors, and establish a relationship between AKI and CKD.

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Key information

Conditions

Postoperative Acute Kidney Injury Pediatric Liver Transplantation

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tianjin First Central Hospital

Tianjin, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who received a liver transplant for the first time.
  • Patients who were younger than 18 years of age at the time of transplant.

Exclusion criteria

  • Patients with incomplete clinical data.
  • Patients with less than 5 years of follow-up.
  • Patients who have combined multiple solid organ transplants.
  • Patients with preoperative renal impairment (eGFR<60ml/min/1.73 m2 or prior renal replacement therapy).

Treatment and study plan

No Intervention: Observational Cohort

Other

no intervention

Primary outcomes

  1. Graft survival

    Time frame: Based on the most recent follow-up before December 31, 2023. The investigators collected clinical data of patients from 2014 to 2018, and followed enrolled participants until at least 5 years after surgery

    Loss of graft is defined as patient death or secondary transplantation

Sponsors and collaborators

Lead sponsor

Tianjin First Central Hospital

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Sep 19, 2024
Registry last updated
Sep 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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