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NCT Number: NCT07194915

Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection (TORPIDS-3)

Pleural infection is a severe and complicated disease which is associated with significant morbidity and mortality. People with pleural infection show diverse levels of neutrophil degranulation activity. The investigators examined the biological role of pleural fluid neutrophil extracellular traps in patients with pleural infection. TORPIDS-3 is an observational, International multicohort study.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Pleural Infection Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CAMS Oxford Institute, Nuffield Department of Medicine

Oxford, United Kingdom

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients were included if they had a clinical presentation consistent with pleural infection as stated in the Methods section of the main manuscript and any of the following criteria:

  • Pleural fluid that was macroscopically purulent, OR
  • Pleural fluid that was positive on culture for bacterial infection, OR
  • Pleural fluid that demonstrated bacteria on Gram staining, OR
  • Pleural fluid with pH ≤7.2 (measured in a blood gas analyser) or low glucose level (≤3mmol/L or ≤55mg/dL) in a patient with clinical evidence of infection, OR
  • Contrast-enhanced CT evidence of pleural infection (consolidation of underlying lung with enhancing pleural collection) in a patient with clinical evidence of infection, alongside exclusion of other sources of infection.

Exclusion criteria

  • Age less than 18 years, OR
  • No pleural fluid available for analysis, OR
  • Patient previous pneumonectomy on the side of pleural infection, OR
  • Expected survival less than three months due to co-morbid disease, as judged by the recruiting physician

Treatment and study plan

Primary outcomes

  1. Disease severity

    Time frame: Baseline

    Association between pleural fluid NETs with disease severity

  2. One-year mortality

    Time frame: Baseline

    Association between pleural fluid NETs and risk of one-year mortality

Secondary outcomes

  1. Bacterial profiles

    Time frame: Baseline

    Association between pleural fluid NETs with bacterial profiles

  2. Sonographic septations

    Time frame: Baseline

    Association between pleural fluid NETs and the presence of sonographic septations

  3. Need for Intrapleural Enzyme Therapy (IET)

    Time frame: Baseline

    Association between pleural fluid NETs with the requirement for IET

Sponsors and collaborators

Lead sponsor

University of Oxford

Other

Collaborators

  • University of Dundee

Registry information

Official study title

Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infection: An Observational, International, Multicohort Study (TORPIDS-3)

Acronym: TORPIDS-3

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 26, 2025
Registry last updated
Sep 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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