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NCT Number: NCT05479474

Platelet Rich Plasma Testis Treatment for Infertile Men

Investigate the effect of intratesticular injection of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in infertile men who already underwent a negative sperm retrieval. Currently, there is no alternative treatment after failed TESE. Prior series suggest that intratesticular PRP injections may improve TESE outcomes. We hope to determine whether PRP is an effective treatment for this patient population.

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Key information

Conditions

Male Infertility Azoospermia Azoospermia, Nonobstructive Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Nonobstructive Azoospermia Urogenital Diseases

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Stanford Urology Clinic

Stanford, California, 94304, United States

Location status: Recruiting

Location contact

Satvir Basran

CONTACT

[email protected]

650-723-0948

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men over the age of 18 diagnosed with NOA and at least one failed TESE, negative mapping or negative biopsy

Exclusion criteria

-

Treatment and study plan

Platelet rich plasma

Biological

Patients will undergo a blood draw (12 tsp) to prepare the PRP infusion. The use of a centrifuge and an Arteriocyte Magellan kit are necessary for the PRP preparation. After injection of local anesthesia, PRP will be injected into each testicle.

  • On the third month after the testicular PRP procedure, a TESE will be performed
  • If the procedure is successful a new IVF cycle using the sperm procured from the procedure will be done.

Primary outcomes

  1. sperm present

    Time frame: 3 months after PRP injection

    A TESE procedure will be performed to determine if sperm are present

Study contacts

Contact information is provided by the study sponsor or research team.

Satvir Basran

CONTACT

[email protected]

650-723-0948

Sponsors and collaborators

Lead sponsor

Stanford University

Other

Registry information

Official study title

Platelet Rich Plasma Testis

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jul 29, 2022
Registry last updated
Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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