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Completed

NCT Number: NCT03167502

Performance in Walking in Osteoarthritis Patients

Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement. This is a randomized, interventional trial.

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Key information

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of rheumatology, nice university hospital

Nice, 06000, France

About this study

Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement, the interest of a work supervised by a sports coach to maintain activity over time and to study the effect of this activity at the muscular level. The main objective is to study the effect of an eccentric muscle strengthening program on walking performance in osteoarthritis patients. The secondary objectives are to study: the effect of fatigue on walking, the relationship between fatigue and the level of physical activity, the effect of training on perceived fatigue and the effect of training on the function and at muscular level. This is a randomized, interventional trial. 40 subjects are planned. Inclusion criteria include: age 40-85 years, KL 2 and 3. The subjects are divided into two groups to perform either eccentric or concentric work. 2 sessions per week for 6 weeks. At baseline and at the end of the study a clinical evaluation and MRI will be carried out for evaluation of the criteria of judgment

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Autonomous subjects aged 40 to 85
  • Subjects meeting ACR criteria for gonarthrosis
  • Subjects with a score of Kellgren and Lawrence at least one knee greater than or equal to 2
  • Signature of consent form
  • Subjects affiliated to social security

Exclusion criteria

Subject with a Kellgren and Lawrence stadium at 4 for at least one of his two knees

  • Subjects with symptomatic femoro-patellar arthrosis
  • Subject with a pathology that makes walking testing impossible.
  • Non-autonomous subjects, with a pathology impairing walking
  • Subjects with symptomatic osteoarthritis of the hip and / or with a hip or knee prosthesis
  • Subject incapable of signing consent and unable to understand information leaflet.

Treatment and study plan

eccentric work

Other

patient will follow 2 eccentric trainings per week during 6 weeks

concentric work

Other

patient will follow 2 concentric trainings per week during 6 weeks

Primary outcomes

  1. Walking performance

    Time frame: after 6 training weeks

    6-minute walk test

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Performance in Walking in Osteoarthritis Patients: the Role of Fatigue and the Effect of an Eccentric Muscle Building Program

Acronym: EX-ART

Important dates

Study start
2017
Primary completion
2017
Study completion
2019
First posted
May 30, 2017
Registry last updated
Mar 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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