Oral Sialic Acid Product Beauty Efficacy Test

Inclusion criteria

• Skin type origin: Asian in China
• Age: from 40 to 65 years old
• Gender: female
• Specific criteria:

• All skin type on the face Dry, dry combination, normal
• presenting with a lack of elasticity to the face, inclusion grade

≤ 6 according 10 points scale

• presenting with a lack of density to the face, inclusion grade ≤ 6 according 10 points scale
• presenting with wrinkles on crow's feet area, grade ≥ 2 according to Skin ageing atlas Vol.2 (p.41)
• presenting with pigmentary spots with at least one with diameter ≥ 3mm
• Usual or occasional user of food supplements
• Able to give her informed consent

Exclusion criteria

The non-inclusion general criteria were the following ones:

• allergies or reactivity to cosmetic products,
• for the subjects undergoing hormonal treatment; change of treatment within 3 months preceding the inclusion visit,
• expectation of change in the current hormonal treatment during the study,
• anti-allergic, antibiotic, anti-inflammatory, dermatological treatment or corticosteroid therapy within 2 weeks before the inclusion visit,
• having a chronic pathology,
• performing or prevision to perform another test during the study or during the exclusion period,
• employee of the COSderma laboratory,
• pregnant or breast-feeding woman,
• woman not taking precaution to prevent pregnancy.

The non-inclusion specific criteria were the following ones:

• application of care products to the face within 48 hours preceding the inclusion visit,
• application of make-up products to the face the day of the inclusion visit,
• face wash with any other means than clear water (no soap or cleanser) on the day of the inclusion visit,
• application of self-tanning products to the face within 4 weeks preceding the inclusion visit,
• Oral intake of food supplement within 1 month preceding the inclusion visit,
• cutaneous marks on the face which could interfere with the skin's clinical signs assessment (pigmentation issues, scar tissues, over-developed hairiness, too many ephelides and naevi, sunburns...),
• solar exposition (natural sun or UVA or heliotherapy treatment) within 4 weeks preceding the inclusion visit and expectation of solar exposition (natural or UVA) during the study,
• Vitamin A acid treatment or its derivatives within 3 months preceding the pre-inclusion visit,
• Retinoid based oral treatment within 6 months before the pre-inclusion visit, or local treatment within 2 months prior to this visit,
• Carotene based treatment within 4 weeks preceding the inclusion visit,
• expectation or having undergone aesthetic or dermatological surgery on the face.