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NCT Number: NCT04645628

Optimization of the Acquisition Sequence to Improve the Quality and Comfort of Magnetic Resonance Imaging Exam

The purpose of this study is to evaluate the optimization of MRI acquisition sequences.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHRU de Nancy

Nancy, 5400, France

Location status: Recruiting

Location contact

Valerie Laurent, Md, PhD

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

for all subjects :

  • to be over 18 year-old,
  • to be able to understand the instructions given,
  • to be enrolled in a social security plan,
  • to have underwent a pre-inclusion medical examination,
  • to give a written consent.

Inclusion criteria

especially for Patients :

  • to perform a MRI examination of the head, neck, spine, thorax, abdomen, pelvis, retroperitoneum, lower limbs, upper limbs or whole body during clinical follow-up care.

Exclusion criteria

for all subjects :

  • any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, … ),
  • subject under a measure of legal protection.

Exclusion criteria

especially for Healthy Subjects :

  • to have a pathology in the anatomical area to be imaged
  • to be employed by the CHRU of Nancy or having the slightest link of subordination with the CHRU of Nancy.

Exclusion criteria

especially for Patients :

  • to have a limited MRI examination time due to a sensitive clinical situation (sedation, unstable hemodynamic state, postoperative).

Treatment and study plan

MRI examination

Other

All subjects (healthy subjects and patients) will have an MRI examination with optimized sequences

Primary outcomes

  1. Image quality based on standard imaging quality criteria.

    Time frame: 6 months after the last inclusion

    The image quality will be appreciated visually at least by a radiologist or a researcher.

Secondary outcomes

  1. Comparison of the Signal to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence).

    Time frame: 6 months after the last inclusion

    Signal to Noise Ratio will be measured in arbitrary units.

  2. Comparison of the Contrast to Noise Ratio obtained by the optimized MRI sequence and the reference situation (standard sequence).

    Time frame: 6 months after the last inclusion

    Contrast to Noise Ratio will be measured in arbitrary units.

  3. Comparison of the acquisition time obtained with the optimized MRI sequence and the reference situation (standard sequence).

    Time frame: 6 months after the last inclusion

    Time acquisition will be evaluated in minutes.

  4. Comparison of blurring and artefacts obtained by the optimized MRI sequence and the reference situation (standard sequence).

    Time frame: 6 months after the last inclusion

    Absence of blurring and artefacts will be assessed by at least one radiologist according to an ordinal scale.

  5. Comparison of the spatial resolution obtained by the optimized MRI sequence and the reference situation (standard sequence).

    Time frame: 6 months after the last inclusion

    Spatial resolution will be measured in mm².

  6. Qualification of the MRI acquisition for a clinical study.

    Time frame: 6 months after the inclusion

    Validation of MRI acquisition by a centralized review center.

  7. Evaluation of intra-subject reproducibility on the same MRI and on two MRIs.

    Time frame: 6 months after the last inclusion

    Measurement of intra-subject reproducibility on the same MRI and on two MRIs by the intra-class correlation coefficient for quantitative measurement or by the kappa coefficient for a qualitative measurement.

Study contacts

Contact information is provided by the study sponsor or research team.

Gabriela HOSSU, PhD

CONTACT

[email protected]

+33383155096

Valérie LAURENT, MD, PhD

CONTACT

[email protected]

+33383154181

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Acronym: AIMANT

Important dates

Study start
2020
Primary completion
2027
Study completion
2028
First posted
Nov 27, 2020
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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