Recruiting

NCT Number: NCT02417714

Prospective Evaluation of Next Generation CT Reconstruction (NextGenIR)

Background:

- Computed Tomography (CT) is a scan that makes detailed pictures of the body. It uses radiation to do that. In 2011, about 85.3 million CT scans were done in the United States. But there is growing concern about the health effects of radiation. There are new and different ways to make CT pictures that use less radiation. Researchers want to learn whether these new methods create images that are similar to images from a traditional CT.

Objective:

- To learn if new CT imaging methods with less radiation make images that are similar to traditional ways.

Eligibility:

- Adults 18 years of age and older who are scheduled for a CT of the chest, abdomen and pelvis with contrast.

Design:

* Researchers will review participants medical records to see if they can be in this study. * Participants may have blood drawn from an arm vein by a needle stick. The blood will be used to make sure they can be in this study and that it is safe for them to have contrast. * During the participants CT scan appointment, one extra scan will be done using low radiation methods. * During a CT scan, the participant lies on a table. A large x-ray machine takes pictures of the body.

Recruiting

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Key information

Conditions

Healthy Subjects

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Institutes of Health Clinical Center

Bethesda, Maryland, 20892, United States

Location status: Recruiting

Location contact

NIH Clinical Center Office of Patient Recruitment (OPR)

CONTACT

[email protected]

800-411-1222 ext. TTY dial 711

About this study

Computed Tomography uses ionizing radiation to make pictures of the body. Different methods of creating CT pictures have been developed that allow reductions in the amount of radiation. The purpose of this research study is to learn whether these new imaging methods using less radiation to create images are similar to the traditional and current method.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

INCLUSION CRITERIA:

Inclusion criteria

for Body CT:

Clinical indication for a chest, abdomen and pelvis CT with contrast
Age equal to or greater than 18 years
Able to understand and willing to sign the Informed Consent Form

Inclusion criteria

for Chest CT:

Clinical indication for a CT with or without contrast that includes the chest
Age equal to or greater than 18 years
Able to understand and willing to sign the Informed Consent Form

Exclusion criteria

for Body CT:

Pregnancy
Serum Cr > 1.5 mg/dL
Clinical CT scan with more than one contrast imaging phase (for example three phase liver)

Exclusion criteria

for Chest CT

Pregnancy

Treatment and study plan

Primary outcomes

Compare with respect to 6 image quality metrics the overall image quality from a research low radiation dose body CT utilizing advanced (model based) iterative reconstruction with a clinical standard radiation dose CT from the same subject.

Time frame: Baseline (Day 0)

Study contacts

Contact information is provided by the study sponsor or research team.

Marcus Y Chen, M.D.

CONTACT

[email protected]

(301) 496-0077

Margaret C Lowery, R.N.

CONTACT

[email protected]

(301) 451-3128

Sponsors and collaborators

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Nih

Registry information

Official study title

Prospective Evaluation of Next Generation CT Reconstruction

Important dates

Study start: 2014
Primary completion: 2026
Study completion: 2026
First posted: Apr 16, 2015
Registry last updated: Jul 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Recruiting